Neural correlates of attention bias to threat in post-traumatic stress disorder.
Neural correlates of attention bias to threat in post-traumatic stress disorder.
复制标题
DOI：
10.1016/j.biopsycho.2012.03.001
复制
发表时间：
2012-05
影响因子：
2.6
通讯作者：
Ressler, Kerry J.
中科院分区：
文献类型：
--
作者：
Fani, Negar;Jovanovic, Tanja;Ely, Timothy D.;Bradley, Bekh;Gutman, David;Tone, Erin B.;Ressler, Kerry J.
注意力偏差已被提出，以促进症状的维持在创伤后应激障碍（PTSD），虽然这些过程的神经相关性还没有得到很好的定义，这是本研究的目标。我们管理的注意力偏差任务，点探针，样本37（19个控制，18 PTSD+）创伤的非裔美国成年人在功能磁共振成像。与对照组相比，PTSD+参与者表现出增加激活的背外侧前额叶皮层（dlPFC）在响应威胁线索试验。此外，在PTSD组中，注意力回避威胁与腹外侧前额叶皮层（vlPFC）和背侧前扣带皮层（dACC）激活的增加相对应，而在对照组中没有观察到这种模式。这些数据提供的证据表明，dlPFC，dACC和vlPFC激活的相对增加代表PTSD个体对威胁的注意力偏差的神经标志物，反映了这种疾病中注意力控制和情绪处理网络的选择性中断。
Attentional biases have been proposed to contribute to symptom maintenance in Posttraumatic Stress Disorder (PTSD), although the neural correlates of these processes have not been well defined; this was the goal of the present study. We administered an attention bias task, the dot probe, to a sample of 37 (19 control, 18 PTSD+) traumatized African-American adults during fMRI. Compared to controls, PTSD+ participants demonstrated increased activation in the dorsolateral prefrontal cortex (dlPFC) in response to threat cue trials. In addition, attentional avoidance of threat corresponded with increased ventrolateral prefrontal cortex (vlPFC) and dorsal anterior cingulate cortex (dACC) activation in the PTSD group, a pattern that was not observed in controls. These data provide evidence to suggest that relative increases in dlPFC, dACC and vlPFC activation represent neural markers of attentional bias for threat in individuals with PTSD, reflecting selective disruptions in attentional control and emotion processing networks in this disorder.
登录
查看更多内容
影响因子：
19.9
作者：
Etkin, Amit;Egner, Tobias;Kalisch, Raffael
通讯作者：
Kalisch, Raffael
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
3.3
作者：
Bryant, RA;Harvey, AG
通讯作者：
Harvey, AG
影响因子：
3.7
作者：
Egner, Tobias;Etkin, Amit;Hirsch, Joy
通讯作者：
Hirsch, Joy
DOI：
10.1196/annals.1417.016
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Bishop, Sonia J.
通讯作者：
Bishop, Sonia J.