Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility.
Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility.
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DOI：
10.1007/s10555-008-9167-2
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发表时间：
2009-06
影响因子：
9.2
通讯作者：
Juliano, R. L.
中科院分区：
文献类型：
--
作者：
Kim, T. Y.;Vigil, D.;Der, C. J.;Juliano, R. L.
DLC-1最初被鉴定为潜在的肿瘤抑制因子。DLC-1的关键生化功能之一是作为GTP酶的Rho家族成员，特别是Rho A-C和Cdc 42的GTP酶活化蛋白（GAP）。由于这些GTP酶与细胞骨架和细胞迁移的调节密切相关，因此DLC-1似乎也会影响这些过程。在这篇综述中，我们研究肌动蛋白骨架的基本方面，以及它如何与细胞运动。然后，我们描绘了DLC-1和它的家庭的其他成员的特点，并描述他们如何可能有多种影响细胞极性，肌动蛋白组织和细胞迁移的调节。
DLC-1 was originally identified as a potential tumor suppressor. One of the key biochemical functions of DLC-1 is to serve as a GTPase activating protein (GAP) for members of the Rho family of GTPases, particularly Rho A-C and Cdc 42. Since these GTPases are critically involved in regulation of the cytoskeleton and cell migration, it seems clear that DLC-1 will also influence these processes. In this review we examine basic aspects of the actin cyoskeleton and how it relates to cell motility. We then delineate the characteristics of DLC-1 and other members of its family, and describe how they may have multiple effects on the regulation of cell polarity, actin organization, and cell migration.
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DLC-1和CTEN的SH2结构域的磷酸酪氨酸独立的相互作用调节局灶性粘附定位和DLC-1的生长抑制活性。
影响因子：
7.8
作者：
Liao, Yi-Chun;Si, Lizhen;White, Ralph W. DeVere;Lo, Su Hao
通讯作者：
Lo, Su Hao
影响因子：
21.3
作者：
Balasubramanian, Nagaraj;Scott, David W.;Schwartz, Martin Alexander
通讯作者：
Schwartz, Martin Alexander
影响因子：
7.8
作者：
CHANG, JH;GILL, S;SETTLEMAN, J;PARSONS, SJ
通讯作者：
PARSONS, SJ
影响因子：
7.5
作者：
Huang, TY;DerMardirossian, C;Bokoch, GM
通讯作者：
Bokoch, GM
影响因子：
50.3
作者：
Kang, YB;Siegel, PM;Massagué, J
通讯作者：
Massagué, J