Associations of ambient hydrogen sulfide exposure with self-reported asthma and asthma symptoms.
Associations of ambient hydrogen sulfide exposure with self-reported asthma and asthma symptoms.
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DOI：
10.1016/j.envres.2013.02.002
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发表时间：
2013-04
影响因子：
8.3
通讯作者：
Balmes, John R.
中科院分区：
文献类型：
--
作者：
Bates, Michael N.;Garrett, Nick;Crane, Julian;Balmes, John R.
长期、低水平的硫化氢（H2S）气体是否是健康影响（包括哮喘）的原因尚不确定。新西兰的罗托鲁瓦市是暴露于地热源的硫化氢含量相对较高的环境中的人口最多的城市。在一项横断面研究中，作者调查了这一人群与哮喘的相关性。2008-2010年期间，共有1，637名18-65岁的成年人参加。住宅和工作场所都有地理编码。家庭和工作场所的H2S暴露估计使用全市范围的被动H2S采样器和克里格网络创建暴露表面。暴露度量基于（1）在家和工作时的时间加权暴露;以及（2）最大暴露（在家或工作）。将暴露估计值作为四分位数输入对数二项式回归模型，并提供协变量数据。两种暴露指标均未显示H2S导致哮喘风险增加的证据。然而，在过去的12个月里，出现了一些与哮喘诊断和哮喘症状相关的风险降低的建议，特别是喘息。使用最大暴露度量，最高暴露四分位数中喘息的患病率为0.80（0.65，0.99），当前哮喘治疗的患病率为0.75（0.52，1.08）。没有证据表明这是“幸存者效应”造成的。该研究没有提供证据表明哮喘风险随着H2S暴露而增加。在较高暴露区域降低风险的建议与最近的证据一致，即H2S在体内具有信号传导功能，包括诱导平滑肌松弛和减少炎症。研究局限性，包括可能的混杂因素，排除了明确的结论。
Whether long-term, low-level hydrogen sulfide (H2S) gas is a cause of health effects, including asthma, is uncertain. Rotorua city, New Zealand, has the largest population exposed, from geothermal sources, to relatively high ambient levels of H2S. In a cross-sectional study, the authors investigated associations with asthma in this population. A total of 1,637 adults, aged 18-65 years, were enrolled during 2008-2010. Residences and workplaces were geocoded. H2S exposures at homes and workplaces were estimated using city-wide networks of passive H2S samplers and kriging to create exposure surfaces. Exposure metrics were based on (1) time-weighted exposures at home and work; and (2) the maximum exposure (home or work). Exposure estimates were entered as quartiles into log-binomial regression models, with covariate data. Neither exposure metric showed evidence of increased asthma risk from H2S. However, some suggestion of exposure-related reduced risks for diagnosed asthma and asthma symptoms, particularly wheezing during the last 12 months, emerged. With the maximum exposure metric, the prevalence ratio for wheeze in the highest exposure quartile was 0.80 (0.65, 0.99) and, for current asthma treatment, 0.75 (0.52, 1.08). There was no evidence that this was caused by a “survivor effect”. The study provided no evidence that asthma risk increases with H2S exposure. Suggestions of a reduced risk in the higher exposure areas are consistent with recent evidence that H2S has signaling functions in the body, including induction of smooth muscle relaxation and reduction of inflammation. Study limitations, including possible confounding, preclude definitive conclusions.
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DOI：
10.1111/j.1467-842x.1997.tb01759.x
发表时间：
1997-10-01
影响因子：
3.5
作者：
Bates, MN;Garrett, N;Read, D
通讯作者：
Read, D
DOI：
10.1080/00039890209601428
发表时间：
2002-09-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Bates, MN;Garrett, N;Shoemack, P
通讯作者：
Shoemack, P
DOI：
10.1111/j.1753-6405.2011.00703.x
发表时间：
2011-06-01
影响因子：
3.5
作者：
Mannetje, Andrea't;Eng, Amanda;Pearce, Neil
通讯作者：
Pearce, Neil
DOI：
10.1097/00043764-200009000-00019
发表时间：
2000-09-01
影响因子：
3.2
作者：
Fuller, DC;Suruda, AJ
通讯作者：
Suruda, AJ
DOI：
10.1097/ede.0b013e3182093c8b
发表时间：
2011-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Schinasi L;Horton RA;Guidry VT;Wing S;Marshall SW;Morland KB
通讯作者：
Morland KB