Medial Arterial Calcification: JACC State-of-the-Art Review.
Medial Arterial Calcification: JACC State-of-the-Art Review.
复制标题
DOI：
10.1016/j.jacc.2021.06.049
复制
发表时间：
2021-09-14
影响因子：
24
通讯作者：
St Hilaire C
中科院分区：
文献类型：
--
作者：
Lanzer P;Hannan FM;Lanzer JD;Janzen J;Raggi P;Furniss D;Schuchardt M;Thakker R;Fok PW;Saez-Rodriguez J;Millan A;Sato Y;Ferraresi R;Virmani R;St Hilaire C
内侧动脉钙化（MAC）是一种不同于动脉粥样硬化的慢性全身性血管疾病，经常但不总是与糖尿病、慢性肾脏疾病和衰老相关。MAC也是一些不太常见的疾病中更复杂表型的一部分。MAC的特征包括中间层内磷酸钙（CaP）的弥散性和进行性沉淀、延长的临床无症状病程以及与慢性肢体威胁性缺血相关的血流动力学损害。MAC增加了血管介入治疗期间并发症的风险，并减轻了其结局。除了罕见的影响ATP代谢的单基因缺陷，MAC的发病机制仍然未知，因果治疗是不可用的。实施遗传学和组学为基础的研究方法，认识到至关重要的CaP热力学有望解开MAC分子发病机制，并提供指导治疗。目前的知识状态有关MAC的审查和未来的前景进行了概述。内侧动脉钙化（MAC）是一种慢性全身性血管疾病，与动脉粥样硬化不同，常与糖尿病、慢性肾病、衰老和大量不常见的疾病相关。MAC的特征包括中间层内磷酸钙（CaP）的弥散性和进行性沉淀以及长期的临床无症状病程，通常导致慢性肢体威胁性缺血。MAC增加了血管介入的风险并减轻了其结局。除了罕见的影响ATP代谢的单基因缺陷，MAC的发病机制仍然未知，因果治疗是不可用的。关于MAC的知识的当前状态和未来的前景进行了概述。
Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from atherosclerosis, frequently, but not always associated with diabetes mellitus, chronic kidney disease, and aging. MAC is also a part of more complex phenotypes in a number of less common diseases. The hallmarks of MAC include disseminated and progressive precipitation of calcium phosphate (CaP) within the medial layer, prolonged clinically silent course, and compromise of hemodynamics associated with chronic limb threatening ischemia. MAC increases the risk of complications during vascular interventions and mitigates their outcomes. With the exception of rare monogenetic defects affecting ATP metabolism, MAC pathogenesis remains unknown and causal therapy is not available. Implementation of genetics and omics-based approaches in research recognizing the critical importance of CaP thermodynamics holds promise to unravel MAC molecular pathogenesis and to provide guidance to therapy. The current state of knowledge concerning MAC is reviewed and future perspectives are outlined. Medial arterial calcification (MAC) is a chronic systemic vascular disorder distinct from atherosclerosis frequently associated with diabetes mellitus, chronic kidney disease, aging and a large number of less common diseases. The hallmarks of MAC include disseminated and progressive precipitation of calcium phosphate (CaP) within the medial layer and prolonged clinically silent course often leading to chronic limb threatening ischemia. MAC increases the risk of vascular interventions and mitigates their outcomes. With the exception of rare monogenetic defects affecting ATP metabolism MAC pathogenesis remains unknown and causal therapy is not available. The current state of knowledge concerning MAC is provided and future perspectives are outlined.
登录
查看更多内容
DOI：
10.1083/jcb.35.1.81
发表时间：
1967-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Anderson HC
通讯作者：
Anderson HC
血管钙化会减慢，但在肾移植后不会退缩。
影响因子：
6
作者：
Alappan HR;Vasanth P;Manzoor S;O'Neill WC
通讯作者：
O'Neill WC
影响因子：
8.2
作者：
EDMONDS, ME;ROBERTS, VC;WATKINS, PJ
通讯作者：
WATKINS, PJ
影响因子：
4.8
作者：
Bon, Nina;Couasnay, Greig;Beck, Laurent
通讯作者：
Beck, Laurent
影响因子：
3.7
作者：
Chavkin, Nicholas W.;Chia, Jia Jun;Crouthamel, Matthew H.;Giachelli, Cecilia M.
通讯作者：
Giachelli, Cecilia M.