Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.
Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.
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DOI：
10.1002/syn.21635
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发表时间：
2013-05
期刊：
影响因子：
2.3
通讯作者：
Khoshbouei, Habibeh
中科院分区：
文献类型：
--
作者：
North, Ashley;Swant, Jarod;Salvatore, Michael F.;Gamble-george, Joyonna;Prins, Petra;Butler, Brittany;Mittal, Mukul K.;Heltsley, Rebecca;Clark, John T.;Khoshbouei, Habibeh
甲基苯丙胺是一种高度成瘾性和神经毒性的精神兴奋剂。它在人类中的使用通常与神经认知障碍有关。这是否由于短期记忆和/或海马可塑性的长期缺陷尚不清楚。最近，我们报道了在年轻小鼠海马CA1区的离体制备中，甲基安非他明增加了基线突触传递并减少了LTP。在目前的研究中，我们测试了一个假设，即在青春期小鼠中反复暴露于甲基苯丙胺的神经毒性方案会降低海马突触可塑性并产生短期记忆缺陷。与我们的预测相反，在暴露于冰毒14天后，海马可塑性或短期记忆没有变化。然而，我们发现，在戒毒的第7、14和21天，暴露于甲基苯丙胺的小鼠表现出空间记忆的缺陷，并伴有海马可塑性的下降。我们的研究结果支持了一种解释，即甲基安非他明暴露的神经毒性水平的有害认知后果可能在戒毒后表现出来并持续存在。因此，治疗策略应考虑甲基苯丙胺暴露的短期和长期后果。
Methamphetamine (METH) is a highly addictive and neurotoxic psychostimulant. Its use in humans is often associated with neurocognitive impairment. Whether this is due to long-term deficits in short-term memory and/or hippocampal plasticity remains unclear. Recently, we reported that METH increases baseline synaptic transmission and reduces LTP in an ex vivo preparation of the hippocampal CA1 region from young mice. In the current study, we tested the hypothesis that a repeated neurotoxic regimen of METH exposure in adolescent mice decreases hippocampal synaptic plasticity and produces a deficit in short-term memory. Contrary to our prediction, there was no change in the hippocampal plasticity or short-term memory when measured after 14 days of METH exposure. However, we found that at 7, 14, and 21 days of drug abstinence, METH-exposed mice exhibited a deficit in spatial memory, which was accompanied by a decrease in hippocampal plasticity. Our results support the interpretation that the deleterious cognitive consequences of neurotoxic levels of METH exposure may manifest and persist after drug abstinence. Therefore, therapeutic strategies should consider short-term as well as long-term consequences of methamphetamine exposure.
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影响因子：
5.3
作者：
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通讯作者：
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影响因子：
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