A segmented pattern of cell death during development of the chick embryo

A segmented pattern of cell death during development of the chick embryo
复制标题

鸡胚胎发育过程中细胞死亡的分段模式

DOI:
--
复制
发表时间:
2004
期刊:
Anatomy and Embryology
影响因子:
--
通讯作者:
Mark Osmond
Mark Osmond
中科院分区:
--
文献类型:
--
作者:
P. Jeffs;Mark Osmond

文献摘要

参考文献

被引文献

相似文献

在鸡胚的早期发育过程中,特定的细胞群以特征性的模式死亡。在这项研究中,尼罗蓝硫酸盐染色被用来揭示一种新的模式,节段性重复细胞死亡的近轴中胚层的鸡之前,第23阶段。这种模式根据胚胎的发育阶段而变化,并向吻尾方向移动,对应于进行中的体节分化。最初,在早期的体节分化过程中,细胞死亡仅限于体节的头侧一半(细胞死亡的头侧模式)。在体节分化为皮肌节和硬节后,死细胞以锥体模式出现在表层组织中,与硬节的中心部分对齐(吻尾)。最后,在神经管和扩张的硬结之间可见小的死亡细胞带。第三种模式(腹侧路径)与硬节尾侧的吻侧部分对齐。我们通过迁移神经嵴的荧光标记表明,这些细胞死亡模式对应于神经嵴迁移的路线。此外,23期鸡胚的连续切片证实,死亡细胞的位置与已知的神经嵴迁移路线和某些神经嵴衍生组织的发育部位相关。
SummaryDuring the early development of the chick embryo, specific groups of cells die in characteristic patterns. In this study, Nile Blue sulphate staining was used to reveal a novel pattern of segmentally repeated cell death in the paraxial mesoderm of the chick prior to stage 23. This pattern varies according to the developmental stage of the embryo and shifts rostrocaudally, corresponding to progressing somite differentiation. Initially, during early somite differentiation, cell death is restricted to the rostral half of the somite (the rostral pattern of cell death). After the somite has differentiated into dermomyotome and sclerotome, dead cells appear in superficial tissues in a pyramidal pattern which lies in register (rostrocaudally) with the central part of the sclerotome. Finally, small bands of dying cells are seen between the neural tube and the expanding sclerotome. This third pattern (the ventral path) lies in register with the rostral part of the caudal half of the sclerotome. We show by fluorescent labelling of the migrating neural crest that these patterns of cell death correspond to the routes of neural crest migration. In addition, serial sectioning of stage 23 chick embryos confirms that the position of dying cells correlates with the known routes of neural crest migration and with the sites of development of certain neural crest-derived tissues.
对鸟类躯干神经嵴细胞迁移的时间和途径的活体染料分析。
DOI: 10.1242/dev.106.4.809
发表时间: 1989
期刊: Development (Cambridge, England)
影响因子: --
作者:
Serbedzija,GN;Bronner-Fraser,M;Fraser,SE
通讯作者: Fraser,SE
T-钙粘蛋白的表达与鸟类胚胎躯干中神经嵴细胞的迁移交替出现。
DOI: 10.1242/dev.111.1.15
发表时间: 1991
期刊: Development (Cambridge, England)
影响因子: --
作者:
Ranscht,B;Bronner-Fraser,M
通讯作者: Bronner-Fraser,M
致畸剂和颅面畸形:与细胞死亡的关系。
DOI: 10.1242/dev.103.supplement.213
发表时间: 1988
期刊: Development (Cambridge, England)
影响因子: --
作者:
Sulik,KK;Cook,CS;Webster,WS
通讯作者: Webster,WS
雏鸡后肢神经突生长的主要途径的发展。
DOI: 10.1016/0012-1606(85)90360-4
发表时间: 1985
影响因子: 2.7
作者:
Tosney,KW;Landmesser,LT
通讯作者: Landmesser,LT
细胞死亡描绘了后肢的轴突通路,并且独立于神经突的生长。
DOI: 10.1016/0012-1606(88)90351-x
发表时间: 1988
影响因子: 2.7
作者:
Tosney,KW;Schroeter,S;Pokrzywinski,JA
通讯作者: Pokrzywinski,JA