The preoperative neutrophil-to-lymphocyte ratio predicts the outcomes of patients with hepatocellular carcinoma and cirrhosis after hepatectomy
The preoperative neutrophil-to-lymphocyte ratio predicts the outcomes of patients with hepatocellular carcinoma and cirrhosis after hepatectomy
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术前中性粒细胞与淋巴细胞比值预测肝细胞癌和肝硬化患者肝切除术后的预后
DOI：
10.1007/s10330-015-0117-5
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
彭宝岗
中科院分区：
文献类型：
--
作者：
沈顺利;李绍强;梁力建;彭宝岗
客观化
本研究旨在探讨术前外周血中性粒细胞/淋巴细胞比率(NLR)对肝细胞癌(HCC)和肝切除术后肝硬变患者预后的预测价值。
方法
这项回顾性研究包括321例接受切除的肝细胞癌患者。根据术前常规血液中的中性粒细胞和淋巴细胞计数计算NLR。对接收器工作特性曲线进行分析，以选择最合适的NLR截止值。分析术前NLR、患者人口统计学、临床和病理资料，包括无病生存期(DFS)和总生存期(OS)。
结果
NLR值与甲胎蛋白水平(χ2=5.876，P=0.015)、肿瘤大小(χ2=32.046，P 0.001)、门静脉癌栓(χ2=4.930，P=0.026)、肿瘤包膜(χ2=7.243，P=0.007)、肿瘤复发(χ2=7.717，P=0.005)相关。多因素分析显示，肿瘤个数、PVTT、肿瘤大小和NLR是预测DFS和OS的独立因素。在有肝细胞癌和肝硬变的患者中，而不是在没有肝硬变的患者中，较大的NLR值预示着较差的术后DFS和OS(均P 0.001)。
结论
作为一种简单、有效的肝癌患者的独立预测指标，术前NLR在准确预测有肝细胞癌和肝硬变患者的术后预后方面发挥了重要作用，而对无肝硬变的患者则无此作用。
Objective
The aim of the study was to investigate the prognostic value of the preoperative peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with hepatocellular cancer (HCC) and cirrhosis after hepatectomy.
Methods
This retrospective study included 321 patients with HCC who underwent resection. The NLR was calculated using the neutrophil and lymphocyte counts in routine preoperative blood tests. Receiver operating characteristic curve analysis was performed to select the most appropriate NLR cutoff value. The preoperative NLR, patient demographics, and clinical and pathological data, including disease-free survival (DFS) and overall survival (OS), were analyzed.
Results
The NLR was correlated with alpha-fetoprotein levels (χ2 = 5.876, P = 0.015), tumor size (χ2 = 32.046, P 0.001), portal vein tumor thrombus (PVTT; χ2 = 4.930, P = 0.026), tumor encapsulation (χ2 = 7.243, P = 0.007), and recurrence (χ2 = 7.717, P = 0.005). Multivariate analyses illustrated that the number of tumors, PVTT, tumor size, and the NLR were independent factors for predicting DFS and OS. In patients with HCC and cirrhosis, but not among those without cirrhosis, a larger NLR predicted poorer postoperative DFS and OS (both P 0.001).
Conclusion
As a simple, effective independent predictor for patients with HCC, the preoperative NLR plays an important role in accurately predicting the postoperative outcomes of patients with HCC and cirrhosis, but not those of patients without cirrhosis.
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影响因子：
6.4
作者：
Schaider, H;Oka, M;Herlyn, M
通讯作者：
Herlyn, M
治疗前中性粒细胞-淋巴细胞比率：肝细胞癌患者生存的独立预测因子。
影响因子：
1.6
作者：
Gao F;Li X;Geng M;Ye X;Liu H;Liu Y;Wan G;Wang X
通讯作者：
Wang X
DOI：
10.1007/978-3-642-03503-6_8
发表时间：
2011-01-01
期刊：
INFLAMMATION AND GASTROINTESTINAL CANCERS
影响因子：
--
作者：
Alison, Malcolm R.;Nicholson, Linda J.;Lin, Wey-Ran
通讯作者：
Lin, Wey-Ran
影响因子：
8.8
作者：
Fondevila, C;Metges, J P;Fuster, J;Grau, J J;Palacin, A;Castells, A;Volant, A;Pera, M
通讯作者：
Pera, M
影响因子：
3.5
作者：
Kim, Do Young;Paik, Yong Han;Han, Kwang Hyub
通讯作者：
Han, Kwang Hyub