Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target.
Autoreactive lymphocytes in multiple sclerosis: Pathogenesis and treatment target.
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多发性硬化症中的自身反应性淋巴细胞：发病机制和治疗目标
DOI：
10.3389/fimmu.2022.996469
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发表时间：
2022
影响因子：
7.3
通讯作者：
Baranwal, Manoj
中科院分区：
文献类型：
--
作者：
Liu, Rongzeng;Du, Shushu;Zhao, Lili;Jain, Sahil;Sahay, Kritika;Rizvanov, Albert;Lezhnyova, Vera;Khaibullin, Timur;Martynova, Ekaterina;Khaiboullina, Svetlana;Baranwal, Manoj
多发性硬化症（MS）是一种以髓鞘结构破坏为特征的中枢神经系统（CNS）慢性炎症性疾病。髓磷脂的缺失导致神经元轴突和细胞体的损伤，这在磁共振成像（MRI）上被识别为脑损伤。多发性硬化症的发病机制在很大程度上仍然未知。然而，免疫机制，特别是与异常淋巴细胞活性相关的免疫机制，是神经元损伤的主要原因。Th1和Th17淋巴细胞群主要与MS发病有关。这些淋巴细胞对于脑源性CD8+ T细胞和Th17淋巴细胞的分化至关重要，这些细胞穿过血脑屏障并靶向中枢神经系统的髓鞘。b淋巴细胞也可能通过产生抗髓鞘碱性蛋白抗体参与MS的发病。在后来的研究中，Treg和Th9细胞的异常功能被确定为MS的原因。本文综述了淋巴细胞的异常功能和计数，以及这些细胞对MS的机制的贡献。此外，我们概述了旨在改善这些淋巴细胞异常功能或计数的新型MS治疗方法。
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by destruction of the myelin sheath structure. The loss of myelin leads to damage of a neuron’s axon and cell body, which is identified as brain lesions on magnetic resonance image (MRI). The pathogenesis of MS remains largely unknown. However, immune mechanisms, especially those linked to the aberrant lymphocyte activity, are mainly responsible for neuronal damage. Th1 and Th17 populations of lymphocytes were primarily associated with MS pathogenesis. These lymphocytes are essential for differentiation of encephalitogenic CD8+ T cell and Th17 lymphocyte crossing the blood brain barrier and targeting myelin sheath in the CNS. B-lymphocytes could also contribute to MS pathogenesis by producing anti-myelin basic protein antibodies. In later studies, aberrant function of Treg and Th9 cells was identified as contributing to MS. This review summarizes the aberrant function and count of lymphocyte, and the contributions of these cell to the mechanisms of MS. Additionally, we have outlined the novel MS therapeutics aimed to amend the aberrant function or counts of these lymphocytes.
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影响因子：
8
作者：
Ahmed SM;Fransen NL;Touil H;Michailidou I;Huitinga I;Gommerman JL;Bar-Or A;Ramaglia V
通讯作者：
Ramaglia V
影响因子：
3.7
作者：
Karussis D;Shor H;Yachnin J;Lanxner N;Amiel M;Baruch K;Keren-Zur Y;Haviv O;Filippi M;Petrou P;Hajag S;Vourka-Karussis U;Vaknin-Dembinsky A;Khoury S;Abramsky O;Atlan H;Cohen IR;Abulafia-Lapid R
通讯作者：
Abulafia-Lapid R
影响因子：
2.7
作者：
Ascherio, Alberto;Munger, Kassandra L.
通讯作者：
Munger, Kassandra L.
影响因子：
7.3
作者：
Bhamidipati K;Silberstein JL;Chaichian Y;Baker MC;Lanz TV;Zia A;Rasheed YS;Cochran JR;Robinson WH
通讯作者：
Robinson WH
DOI：
10.1084/jem.20111675
发表时间：
2012-05-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barr TA;Shen P;Brown S;Lampropoulou V;Roch T;Lawrie S;Fan B;O'Connor RA;Anderton SM;Bar-Or A;Fillatreau S;Gray D
通讯作者：
Gray D