Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases.
Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases.
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线粒体铁蛋白在脑铁稳态和神经退行性疾病调节中的作用
DOI：
10.3389/fphar.2014.00019
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发表时间：
2014
影响因子：
5.6
通讯作者：
Chang YZ
中科院分区：
文献类型：
--
作者：
Gao G;Chang YZ
线粒体铁蛋白（mitochondrialferritin，FtMt）是线粒体中一种新的铁储存蛋白。有证据表明，FtMt在结构和功能上与胞浆H-链铁蛋白相似。它保护线粒体免受铁诱导的氧化损伤，可能是通过螯合潜在有害的过量游离铁。它还参与调节铁在细胞质和线粒体内容物之间的分配。与普遍表达的H-铁蛋白不同，FtMt主要在睾丸和脑中表达，这表明其组织相关性作用。FtMt参与神经退行性疾病的发病机制，因为在阿尔茨海默病、不宁腿综合征和弗里德赖希共济失调中已经观察到其表达增加。我们实验室的研究表明，在阿尔茨海默病中，FtMt过表达减弱了β-淀粉样蛋白诱导的神经毒性，另一方面，当FtMt表达被敲低时，β-淀粉样蛋白诱导的神经毒性显著增加。研究还发现，通过维持线粒体铁稳态，FtMt可以防止6-羟基多巴胺诱导的帕金森病多巴胺能细胞损伤。本文就近年来有关FtMt在调节脑内铁稳态及在神经退行性疾病发病机制中的保护作用的研究结果进行综述。
Mitochondrial ferritin (FtMt) is a novel iron-storage protein in mitochondria. Evidences have shown that FtMt is structurally and functionally similar to the cytosolic H-chain ferritin. It protects mitochondria from iron-induced oxidative damage presumably through sequestration of potentially harmful excess free iron. It also participates in the regulation of iron distribution between cytosol and mitochondrial contents. Unlike the ubiquitously expressed H-ferritin, FtMt is mainly expressed in testis and brain, which suggests its tissue-related roles. FtMt is involved in pathogenesis of neurodegenerative diseases, as its increased expression has been observed in Alzheimer’s disease, restless legs syndrome and Friedreich’s ataxia. Studies from our laboratory showed that in Alzheimer’s disease, FtMt overexpression attenuated the β-amyloid induced neurotoxicity, which on the other hand increased significantly when FtMt expression was knocked down. It is also found that, by maintaining mitochondrial iron homeostasis, FtMt could prevent 6-hydroxydopamine induced dopaminergic cell damage in Parkinson’s disease. These recent findings on FtMt regarding its functions in regulation of brain iron homeostasis and its protective role in pathogenesis of neurodegenerative diseases are summarized and reviewed.
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影响因子：
5.6
作者：
Bou-Abdallah, F;Santambrogio, P;Chasteen, ND
通讯作者：
Chasteen, ND
影响因子：
9.9
作者：
Connor, JR;Wang, XS;Allen, RP
通讯作者：
Allen, RP
DOI：
10.1111/j.1440-1681.2011.05661.x
发表时间：
2012-08-01
影响因子：
2.9
作者：
Anderson, Gregory J.;Wang, Fudi
通讯作者：
Wang, Fudi
影响因子：
8
作者：
Lozoff, B;Jimenez, F;Wolf, AW
通讯作者：
Wolf, AW
影响因子：
9.9
作者：
Connor, JR;Boyer, PJ;Earley, CJ
通讯作者：
Earley, CJ