Malaria resurgence: a systematic review and assessment of its causes.
Malaria resurgence: a systematic review and assessment of its causes.
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DOI：
10.1186/1475-2875-11-122
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发表时间：
2012-04-24
期刊：
影响因子：
3
通讯作者：
Moonen B
中科院分区：
文献类型：
--
作者：
Cohen JM;Smith DL;Cotter C;Ward A;Yamey G;Sabot OJ;Moonen B
自2000年以来，疟疾发病率大幅度下降，同时防治资金也有所增加，但历史上未能保持防治疟疾的成果，突出表明这些成果的脆弱性。虽然疟疾传播可以通过有效的控制措施加以遏制，但如果不采取积极的干预措施，疟疾将恢复到由生态、蚊媒效率和社会经济特征等因素决定的内在平衡状态。了解历史上在何处以及为什么会出现疟疾复发，可以帮助当前和未来的疟疾控制规划避免过去的错误。对文献进行了系统回顾，以确定历史上的疟疾复发事件。这些事件的所有可能原因都根据它们是否与疟疾控制方案减弱、疟疾传播可能性增加或抗药性等技术障碍有关进行了分类。审查发现，从1930年代到2000年代，61个国家发生了75起死灰复燃事件。几乎所有复发事件（68/75 = 91%）至少部分归因于疟疾控制规划因各种原因而减弱，其中资源限制是最常见的（39/68 = 57%）。超过一半的事件（44/75 = 59%）部分归因于疟疾传播内在潜力的增加，而只有24/75（32%）归因于病媒或耐药性。鉴于大多数疟疾复发都与控制方案的削弱有关，迫切需要制定切实可行的解决办法，消除财政和业务方面的威胁，以有效维持当今成功的疟疾控制方案。
Considerable declines in malaria have accompanied increased funding for control since the year 2000, but historical failures to maintain gains against the disease underscore the fragility of these successes. Although malaria transmission can be suppressed by effective control measures, in the absence of active intervention malaria will return to an intrinsic equilibrium determined by factors related to ecology, efficiency of mosquito vectors, and socioeconomic characteristics. Understanding where and why resurgence has occurred historically can help current and future malaria control programmes avoid the mistakes of the past. A systematic review of the literature was conducted to identify historical malaria resurgence events. All suggested causes of these events were categorized according to whether they were related to weakened malaria control programmes, increased potential for malaria transmission, or technical obstacles like resistance. The review identified 75 resurgence events in 61 countries, occurring from the 1930s through the 2000s. Almost all resurgence events (68/75 = 91%) were attributed at least in part to the weakening of malaria control programmes for a variety of reasons, of which resource constraints were the most common (39/68 = 57%). Over half of the events (44/75 = 59%) were attributed in part to increases in the intrinsic potential for malaria transmission, while only 24/75 (32%) were attributed to vector or drug resistance. Given that most malaria resurgences have been linked to weakening of control programmes, there is an urgent need to develop practical solutions to the financial and operational threats to effectively sustaining today’s successful malaria control programmes.
影响因子：
2.7
作者：
Akhtar, R.;Learmonth, A.
通讯作者：
Learmonth, A.