Walking the walk: how kinesin and dynein coordinate their steps.
Walking the walk: how kinesin and dynein coordinate their steps.
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DOI:
10.1016/j.ceb.2008.12.002
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发表时间:
2009-02
影响因子:
7.5
通讯作者:
Vale RD
中科院分区:
文献类型:
--
作者:
Gennerich A;Vale RD
Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
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DOI:
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发表时间:
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期刊:
The Journal of cell biology
影响因子:
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发表时间:
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