Content, pattern and metabolic processing of rat-liver gangliosides during liver regeneration.
Content, pattern and metabolic processing of rat-liver gangliosides during liver regeneration.
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肝再生过程中大鼠肝神经节苷脂的含量、模式和代谢过程。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
G. Tettamanti
中科院分区：
文献类型：
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作者：
L. Riboni;R. Ghidoni;A. Benevento;G. Tettamanti
在大鼠肝再生过程中，肝部分切除后神经节苷脂的含量和分布发生了显著变化，术后第4天肝神经节苷脂总量显著增加，此后逐渐下降，第12天达到假手术对照组的值。在第4天，GD 1a相对增加了95%，GD 1b相对减少了40%。为了研究神经节苷脂渗透进入细胞、降解和生物合成的过程，给予放射性标记的GM 1（[Sph-3 H] GM 1）。肝切除后第1天，肝脏对外源性神经节苷脂的摄取和代谢明显减少。术后3天，这些参数恢复至对照值;然而，在GD 1a中发现放射性掺入增加，因此表明其生物合成在第4天左右增强。这里报告的数据表明，在部分肝切除术后的前两天，神经节苷脂降解减少，神经节苷脂含量随之增加;后来的分解代谢途径正常化，一些生物合成过程导致GD 1a增强。GD 1a似乎是肝再生特殊过渡阶段的标志物。
During rat liver regeneration, the ganglioside content and distribution undergo significant changes after partial hepatectomy; total liver gangliosides increase remarkably till the 4th day after surgery, thereafter progressively decreasing to reach the values of sham-operated controls at the 12th day. The qualitative pattern is characterized by the 95% relative increase of GD1a at the 4th day and the 40% relative decrease of GD1b. In order to investigate the processes of ganglioside penetration into cells, degradation and biosynthesis, radiolabelled GM1 ([Sph-3H] GM1) was administered. One day after hepatectomy the liver uptake and metabolism of exogenous ganglioside were significantly reduced. Three days post-surgery these parameters were restored to control values; however an increased radioactivity incorporation was found in GD1a, thus suggesting an enhancement of its biosynthesis around the 4th day. The data reported here suggest that in the first two days after partial hepatectomy, the ganglioside degradation is reduced with a consequent increase of ganglioside content; later on the catabolic routes normalize and some biosynthetic processes leading to GD1a are enhanced. GD1a seems to be a marker of a peculiar transition phase of liver regeneration.
影响因子：
2.9
作者：
LADISCH, S;GILLARD, B
通讯作者：
GILLARD, B
神经节苷脂对蛋白激酶 C 活性的调节。
DOI：
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发表时间：
1987
期刊：
The Journal of biological chemistry
影响因子：
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作者：
Kreutter,D;Kim,JY;Goldenring,JR;Rasmussen,H;Ukomadu,C;DeLorenzo,RJ;Yu,RK
通讯作者：
Yu,RK
肝再生中的去唾液酸糖蛋白受体。
DOI：
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发表时间：
1982
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Howard,DJ;Stockert,RJ;Morell,AG
通讯作者：
Morell,AG