Contrasting signatures of population growth for mitochondrial DNA and Y chromosomes among human populations in Africa.
Contrasting signatures of population growth for mitochondrial DNA and Y chromosomes among human populations in Africa.
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非洲人群线粒体 DNA 和 Y 染色体的人口增长特征对比。
DOI：
10.1093/molbev/msm279
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发表时间：
2008
影响因子：
10.7
通讯作者：
Hammer,MichaelF
中科院分区：
文献类型：
--
作者：
Pilkington,MayaMetni;Wilder,JasonA;Mendez,FernandoL;Cox,MurrayP;Woerner,August;Angui,Thiep;Kingan,Sarah;Mobasher,Zahra;Batini,Chiara;Destro-Bisol,Giovanni;Soodyall,Himla;Strassmann,BeverlyI;Hammer,MichaelF
更新世人口扩张的历史已经从许多人类种群的线粒体DNA（mtDNA）多态性的频谱中推断出来。在常染色体和X连锁基因座中通常没有观察到类似的模式。这种差异的一个解释是最近的人口瓶颈，与不同的恢复率为单倍体和常染色体基因座作为其不同的有效人口规模的结果。这一假设预测，线粒体和Y染色体DNA将显示出类似的倾斜频谱中的人口经历了最近的有效人口规模的增加。我们测试这一假设的重新测序6.6 kb的非编码Y染色体DNA和780个碱基对的mtDNA细胞色素c氧化酶亚基III（COIII）基因在172名男性从5个非洲人口。对每个群体中的每个位点采用四种群体扩展检验：Fu'sFs统计量、R2统计量、合并模拟和错配分布。与以前的研究结果一致，mtDNA多态性的模式更好地适合一个模型的人口规模恒定的食物采集人口和人口扩张的粮食生产人口的模型。相比之下，没有一项测试显示食物采集者或食物生产者的Y染色体生长的证据。不同的mtDNA和Y染色体多态性模式最有可能反映了非洲人口近代史上性别偏见的人口统计学过程。我们假设，男性经历了较小的有效人口规模和/或较低的迁移率在班图扩张，这发生在过去的5,000年。
A history of Pleistocene population expansion has been inferred from the frequency spectrum of polymorphism in the mitochondrial DNA (mtDNA) of many human populations. Similar patterns are not typically observed for autosomal and X-linked loci. One explanation for this discrepancy is a recent population bottleneck, with different rates of recovery for haploid and autosomal loci as a result of their different effective population sizes. This hypothesis predicts that mitochondrial and Y chromosomal DNA will show a similar skew in the frequency spectrum in populations that have experienced a recent increase in effective population size. We test this hypothesis by resequencing 6.6 kb of noncoding Y chromosomal DNA and 780 basepairs of the mtDNAcytochrome c oxidase subunit III(COIII) gene in 172 males from 5 African populations. Four tests of population expansion are employed for each locus in each population: Fu'sFsstatistic, theR2statistic, coalescent simulations, and the mismatch distribution. Consistent with previous results, patterns of mtDNA polymorphism better fit a model of constant population size for food-gathering populations and a model of population expansion for food-producing populations. In contrast, none of the tests reveal evidence of Y chromosome growth for either food-gatherers or food-producers. The distinct mtDNA and Y chromosome polymorphism patterns most likely reflect sex-biased demographic processes in the recent history of African populations. We hypothesize that males experienced smaller effective population sizes and/or lower rates of migration during the Bantu expansion, which occurred over the last 5,000 years.
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DOI：
10.1073/pnas.97.13.7360
发表时间：
2000-06-20
影响因子：
11.1
作者：
Thomson, R;Pritchard, JK;Feldman, MW
通讯作者：
Feldman, MW
影响因子：
10.7
作者：
Hey, J
通讯作者：
Hey, J
影响因子：
1.5
作者：
Nachman, MW
通讯作者：
Nachman, MW
影响因子：
3.3
作者：
Yunxin Fu
通讯作者：
Yunxin Fu
人类的排卵期是隐藏的吗？
影响因子：
3.8
作者：
F. Marlowe
通讯作者：
F. Marlowe