The circadian clock coordinates ribosome biogenesis.
The circadian clock coordinates ribosome biogenesis.
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DOI：
10.1371/journal.pbio.1001455
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发表时间：
2013
期刊：
影响因子：
9.8
通讯作者：
Gachon F
中科院分区：
文献类型：
--
作者：
Jouffe C;Cretenet G;Symul L;Martin E;Atger F;Naef F;Gachon F
作者确定了生物钟在核糖体生物合成过程中协调mRNA翻译的新作用，核糖体生物合成是细胞代谢的关键过程。生物节律在大多数生物体的生理和行为中起着重要作用。生物钟控制的基因的节律性昼夜表达是由依赖于转录调节因子的相互连接的负反馈环的分子钟协调的。在这里，我们表明，生物钟也通过mRNA翻译的调节发挥其功能。也就是说，生物钟通过控制翻译起始因子的转录以及参与其调节的信号通路的时钟依赖性节律激活来影响参与核糖体生物合成的mRNA子集的时间翻译。此外，昼夜节律振荡器直接调节核糖体蛋白mRNA和核糖体RNA的转录。因此，生物钟在协调核糖体生物合成的转录和翻译步骤中发挥重要作用。地球上的大多数生物体都呈现出生物节律，这些生物节律在其生理和行为的协调中发挥着重要作用。分子生物钟的发现为了解这些节律的产生机制提供了重要的见解。事实上，这种分子钟协调了参与代谢不同方面的时钟控制基因的节奏转录，例如肝脏中的脂质，碳水化合物和异生物质代谢。然而，我们在这里表明，生物钟也可以通过协调mRNA翻译发挥其功能。也就是说，生物钟通过控制翻译起始因子的表达和激活以及参与其调节的信号传导途径的时钟依赖性节律激活来影响mRNA子集的时间翻译。这些有节奏地翻译的mRNA主要参与核糖体生物合成，这是一个消耗能量的过程，必须在细胞资源不太有限的时期进行门控。此外，昼夜节律振荡器在这一过程中的作用是通过其直接调节核糖体蛋白mRNA和核糖体RNA的转录而突出的。因此，我们的研究结果表明，生物钟发挥了重要作用，在协调转录和翻译步骤的核糖体生物合成。
The authors identify a new role of the circadian clock in coordinating mRNA translation during ribosome biogenesis, a key process for cell metabolism. Biological rhythms play a fundamental role in the physiology and behavior of most living organisms. Rhythmic circadian expression of clock-controlled genes is orchestrated by a molecular clock that relies on interconnected negative feedback loops of transcription regulators. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of translation initiation factors as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. Moreover, the circadian oscillator directly regulates the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis. Most living organisms on earth present biological rhythms that play a fundamental role in the coordination of their physiology and behavior. The discovery of the molecular circadian clock gives important insight into the mechanisms involved in the generation of these rhythms. Indeed, this molecular clock orchestrates the rhythmic transcription of clock-controlled genes involved in different aspects of metabolism, for example lipid, carbohydrate, and xenobiotic metabolisms in the liver. However, we show here that the circadian clock could also exert its function through the coordination of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs by controlling the expression and activation of translation initiation factors, as well as the clock-dependent rhythmic activation of signaling pathways involved in their regulation. These rhythmically translated mRNAs are mainly involved in ribosome biogenesis, an energy consuming process, which has to be gated to a period when the cell resources are less limited. Moreover, the role of the circadian oscillator in this process is highlighted by its direct regulation of the transcription of ribosomal protein mRNAs and ribosomal RNAs. Thus our findings suggest that the circadian clock exerts a major role in coordinating transcription and translation steps underlying ribosome biogenesis.
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影响因子：
32.4
作者：
Asmal, M;Colgan, J;Luban, J
通讯作者：
Luban, J
昼夜节律的代谢和能量学的融合。
DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
2.9
作者：
CHOMCZYNSKI, P;SACCHI, N
通讯作者：
SACCHI, N
DOI：
10.18632/aging.100241
发表时间：
2010-12
期刊：
Aging
影响因子：
--
作者：
Dubrovsky YV;Samsa WE;Kondratov RV
通讯作者：
Kondratov RV
影响因子：
29
作者：
Gachon, Federic;Olela, Fabienne Fleury;Schibler, Ueli
通讯作者：
Schibler, Ueli