Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.
Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome.
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DOI：
10.1016/j.jaci.2014.07.026
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发表时间：
2014-11
影响因子：
14.2
通讯作者：
Rothenberg, Marc E.
中科院分区：
文献类型：
--
作者：
Caldwell, Julie M.;Collins, Margaret H.;Stucke, Emily M.;Putnam, Philip E.;Franciosi, James P.;Kushner, Jonathan P.;Abonia, J. Pablo;Rothenberg, Marc E.
嗜酸性胃炎（EG）的定义目前仅限于基于组织嗜酸性粒细胞计数的组织学EG。我们的目的是提供额外的基本信息的分子，组织病理学和临床特征的EG。在EG和对照患者中分析全基因组转录谱和胃活检的组织学特征以及血液嗜酸性粒细胞数目（各n = 15）。胃窦嗜酸性粒细胞计数峰值在EG组为282.7 ± 163.9个嗜酸性粒细胞/400 X高倍视野（HPF），对照组为11.0 ± 8.5个嗜酸性粒细胞/HPF（P = 6.1 × 10−7）。EG患者（87%）在多个胃肠道节段中共存嗜酸性粒细胞炎症;食管是最常见的继发部位。外周血嗜酸性粒细胞数量升高（EG 1.09 ± 0.88 × 103 [K]/μl vs.对照组0.09 ± 0.08 K/μl，P = .0027）与胃嗜酸性粒细胞峰值计数呈正相关（Pearson r2 = .8102，P < .0001）。MIB-1+（增殖）、CD 117+（肥大细胞）和FOXP 3+细胞（调节和/或活化T细胞）在EG中增加。转录谱显示EG胃组织中8%的基因组发生变化。只有7%的EG转录组与嗜酸性粒细胞性食管炎（EoE）转录组重叠。观察到IL 4、IL 5、IL 13、IL 17、CCL 26和肥大细胞特异性转录物显著增加，而IL 33降低。EG是一种全身性疾病，涉及严重的血液和胃肠道嗜酸性粒细胞增多症、Th 2免疫和与EoE转录组明显不同的保守的胃转录组。本文的数据定义密切相关的细胞和分子途径的EG，并提供了基础，以改善诊断和治疗。
The definition of eosinophilic gastritis (EG) is currently limited to histological EG based on the tissue eosinophil count. We aimed to provide additional fundamental information about the molecular, histopathological, and clinical characteristics of EG. Genome-wide transcript profiles and histological features of gastric biopsies as well as blood eosinophil numbers were analyzed in EG and control patients (n = 15 each). The peak gastric antrum eosinophil count was 282.7 ± 163.9 eosinophils/400X high-power field (HPF) in EG and 11.0 ± 8.5 eosinophils/HPF in control patients (P = 6.1 × 10−7). EG patients (87%) had co-existing eosinophilic inflammation in multiple gastrointestinal segments; the esophagus represented the most common secondary site. Elevated peripheral blood eosinophil numbers (EG 1.09 ± 0.88 × 103 [K]/μl vs. control 0.09 ± 0.08 K/μl, P = .0027) positively correlated with peak gastric eosinophil counts (Pearson r2 = .8102, P < .0001). MIB-1+ (proliferating), CD117+ (mast cells), and FOXP3+ cells (regulatory and/or activated T cells) were increased in EG. Transcript profiling revealed changes in 8% of the genome in EG gastric tissue. Only 7% of this EG transcriptome overlapped with the eosinophilic esophagitis (EoE) transcriptome. Significantly increased IL4, IL5, IL13, IL17, CCL26 and mast cell-specific transcripts and decreased IL33 were observed. EG is a systemic disorder involving profound blood and gastrointestinal tract eosinophilia, Th2 immunity, and a conserved gastric transcriptome markedly distinct from the EoE transcriptome. The data herein define germane cellular and molecular pathways of EG and provide a basis for improving diagnosis and treatment.
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DOI：
10.1084/jem.20130240
发表时间：
2013-09-23
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Islam SA;Ling MF;Leung J;Shreffler WG;Luster AD
通讯作者：
Luster AD
影响因子：
14.2
作者：
Abonia, J. Pablo;Blanchard, Carine;Butz, Bridget Buckmeier;Rainey, Heather F.;Collins, Margaret H.;Stringer, Keith;Putnam, Philip E.;Rothenberg, Marc E.
通讯作者：
Rothenberg, Marc E.
影响因子：
4.4
作者：
Dufort, Fay J.;Bleiman, Blair F.;Chiles, Thomas C.
通讯作者：
Chiles, Thomas C.
影响因子：
9.1
作者：
JAFFE, JS;JAMES, SP;METCALFE, DD
通讯作者：
METCALFE, DD
DOI：
10.1097/mpg.0b013e3181e0817b
发表时间：
2010-09-01
影响因子：
2.9
作者：
Fuentebella, Judy;Patel, Anup;Nadeau, Kari
通讯作者：
Nadeau, Kari