Spike count, spike timing and temporal information in the cortex of awake, freely moving rats.
Spike count, spike timing and temporal information in the cortex of awake, freely moving rats.
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DOI：
10.1088/1741-2560/11/4/046022
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发表时间：
2014-08
影响因子：
4
通讯作者：
Moxon KA
中科院分区：
文献类型：
--
作者：
Scaglione A;Foffani G;Moxon KA
周围信息的感觉处理不是静止的，而是一个与动物行为状态相关的动态过程。然而，行为状态与神经元编码特性之间的联系尚不清楚。本报告研究了在清醒、自由运动的大鼠中，行为状态对皮质神经元用于检测和辨别体感刺激的编码机制的影响。在两种不同的行为状态下（安静和快速），记录了5只大鼠初级体感觉皮层的神经元活动，同时增加电刺激强度到神秘垫。然后使用信息理论测量来测量不同编码机制对须刺激下神经元携带信息的贡献。我们发现，动物的行为状态调节了神经元传递的信息总量，与单独的峰值总数相比，单个峰值的时间增加了信息总量。然而，时间信息，即只与峰值发生时间相关的信息，不受行为状态的调节。我们认为，体感刺激信息受动物行为的调节，这种调节主要表现在脉冲数上，而时间信息对行为状态的变化更为稳健。
Sensory processing of peripheral information is not stationary but is, in general, a dynamic process related to the behavioral state of the animal. Yet the link between the state of the behavior and the encoding properties of neurons is unclear. This report investigates the impact of the behavioral state on the encoding mechanisms used by cortical neurons for both detection and discrimination of somatosensory stimuli in awake, freely moving, rats. Neuronal activity was recorded from the primary somatosensory cortex of five rats under two different behavioral states (quiet vs. whisking) while electrical stimulation of increasing stimulus strength was delivered to the mystacial pad. Information theoretical measures were then used to measure the contribution of different encoding mechanisms to the information carried by neurons in response to the whisker stimulation. We found that the behavioral state of the animal modulated the total amount of information conveyed by neurons and that the timing of individual spikes increased the information compared to the total count of spikes alone. However, the temporal information, i.e. information exclusively related to when the spikes occur, was not modulated by behavioral state. We conclude that information about somatosensory stimuli is modulated by the behavior of the animal and this modulation is mainly expressed in the spike count while the temporal information is more robust to changes in behavioral state.
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影响因子：
5.3
作者：
Aguilar, JR;Castro-Alamancos, MA
通讯作者：
Castro-Alamancos, MA
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
HOPFIELD, JJ
通讯作者：
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