Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family
Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family
复制标题
果蝇着丝粒凝聚蛋白 MEI-S332 家族的作用和调控
DOI：
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
T. Orr
中科院分区：
文献类型：
--
作者：
Janice Y. Lee;Aki Hayashi;T. Orr
在减数分裂中，姐妹染色单体的着丝粒之间的物理附着或内聚一直保持到它们在后期II分离。这种内聚对于确保姐妹染色单体在减数分裂II中准确分离和避免非整倍体（一种可能导致产前死亡或出生缺陷的情况）至关重要。果蝇MEI-S332蛋白在姐妹染色单体在有丝分裂和减数分裂中附着时定位于着丝粒，并且在I中期/ I后期过渡时姐妹染色单体臂上的内聚丧失后，它需要维持着丝粒上的内聚。MEI-S332是一个保护着丝粒内聚的蛋白家族的创始成员，但其成员也影响着着丝粒行为和纺锤体微管动力学。我们比较了果蝇MEI-S332家族成员，评估了MEI-S332在有丝分裂和减数分裂I中的作用，并讨论了MEI-S332在着丝粒定位及其后期解离的调控。我们分析了MEI-S332与内聚蛋白之间的关系，内聚蛋白是一种蛋白质复合物，也是有丝分裂和减数分裂中姐妹染色单体内聚所必需的。在有丝分裂中，MEI-S332的着丝粒定位不依赖于黏结蛋白复合物，即使在没有MEI-S332的情况下，黏结蛋白仍与有丝分裂染色体保持联系。
In meiosis, a physical attachment, or cohesion, between the centromeres of the sister chromatids is retained until their separation at anaphase II. This cohesion is essential for ensuring accurate segregation of the sister chromatids in meiosis II and avoiding aneuploidy, a condition that can lead to prenatal lethality or birth defects. The Drosophila MEI-S332 protein localizes to centromeres when sister chromatids are attached in mitosis and meiosis, and it is required to maintain cohesion at the centromeres after cohesion along the sister chromatid arms is lost at the metaphase I/anaphase I transition. MEI-S332 is the founding member of a family of proteins that protect centromeric cohesion but whose members also affect kinetochore behaviour and spindle microtubule dynamics. We compare the Drosophila MEI-S332 family members, evaluate the role of MEI-S332 in mitosis and meiosis I, and discuss the regulation of localization of MEI-S332 to the centromere and its dissociation at anaphase. We analyse the relationship between MEI-S332 and cohesin, a protein complex that is also necessary for sister-chromatid cohesion in mitosis and meiosis. In mitosis, centromere localization of MEI-S332 is not dependent upon the cohesin complex, and cohesin retains its association with mitotic chromosomes even in the absence of MEI-S332.
Spo13 调节粘连蛋白裂解。
DOI：
10.1101/gad.989302
发表时间：
2002
期刊：
Genes & development.
影响因子：
--
作者：
Lee,BrianH;Amon,Angelika;Prinz,Susanne
通讯作者：
Prinz,Susanne
果蝇 mei-S332 基因在着丝粒分化后的减数分裂中促进姐妹染色单体的凝聚。
影响因子：
3.3
作者：
Kerrebrock,AW;Miyazaki,WY;Birnby,D;Orr-Weaver,TL
通讯作者：
Orr-Weaver,TL