The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
The relevance of rich club regions for functional outcome post-stroke is enhanced in women.
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DOI：
10.1002/hbm.26159
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发表时间：
2023-03
影响因子：
4.8
通讯作者：
中科院分区：
文献类型：
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本研究旨在研究预先定义的高度互连（富俱乐部）脑区中的卒中病变对卒中后功能结局的影响，确定其空间特异性并探索生物性别对其相关性的影响。我们分析了首次卒中时记录的MRI数据和入组多部位MRI ‐ GENIE研究的急性缺血性卒中患者的约3个月改良兰金量表（mRS）数据。将空间标准化的结构性卒中病变分成108个图谱定义的双侧（亚）皮质脑区域。在贝叶斯逻辑回归框架中对不利结果（mRS> 2）进行建模。单个大脑区域的效应被捕获为两个复合效应，分别针对（i）6个双侧丰富俱乐部和（ii）所有其他非丰富俱乐部区域。在空间特异性分析中，我们将其随机分为"富人俱乐部"和"非富人俱乐部"区域，并将实际富人俱乐部区域的影响与6个随机区域的1000种组合的影响分布进行比较。在特定性别的分析中，我们在模型结构中引入了一个额外的层次，以比较男性和女性特定的富人俱乐部效应。共分析了822例患者（年龄：64.7 [15.0]，39%为女性）。丰富的俱乐部区域在解释不利的功能结果方面具有实质性的相关性（后验分布的平均值：0.08，曲线下面积：0.8）。特别是，丰富的俱乐部组合比98.4%的随机星座具有更高的相关性。在解释女性的长期结果方面，富裕俱乐部区域比男性更重要。总而言之，在丰富的俱乐部区域的病变与不利结果的几率增加有关。这些影响是空间特异性的，在女性中更为明显。在丰富的俱乐部区域的病变与不利结果的几率增加有关。这些效应具有空间特异性，即6个区域的大多数随机组合对长期结局的影响较小。对女性的影响要明显得多。
This study aimed to investigate the influence of stroke lesions in predefined highly interconnected (rich‐club) brain regions on functional outcome post‐stroke, determine their spatial specificity and explore the effects of biological sex on their relevance. We analyzed MRI data recorded at index stroke and ~3‐months modified Rankin Scale (mRS) data from patients with acute ischemic stroke enrolled in the multisite MRI‐GENIE study. Spatially normalized structural stroke lesions were parcellated into 108 atlas‐defined bilateral (sub)cortical brain regions. Unfavorable outcome (mRS > 2) was modeled in a Bayesian logistic regression framework. Effects of individual brain regions were captured as two compound effects for (i) six bilateral rich club and (ii) all further non‐rich club regions. In spatial specificity analyses, we randomized the split into “rich club” and “non‐rich club” regions and compared the effect of the actual rich club regions to the distribution of effects from 1000 combinations of six random regions. In sex‐specific analyses, we introduced an additional hierarchical level in our model structure to compare male and female‐specific rich club effects. A total of 822 patients (age: 64.7[15.0], 39% women) were analyzed. Rich club regions had substantial relevance in explaining unfavorable functional outcome (mean of posterior distribution: 0.08, area under the curve: 0.8). In particular, the rich club‐combination had a higher relevance than 98.4% of random constellations. Rich club regions were substantially more important in explaining long‐term outcome in women than in men. All in all, lesions in rich club regions were associated with increased odds of unfavorable outcome. These effects were spatially specific and more pronounced in women. Lesions in rich club regions were associated with increased odds of unfavorable outcome. These effects were spatially specific, that is, the majority of random combinations of six regions had comparably smaller effects on long‐term outcome. Effects were substantially more pronounced in women.
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影响因子：
4.8
作者：
Bonkhoff AK;Rehme AK;Hensel L;Tscherpel C;Volz LJ;Espinoza FA;Gazula H;Vergara VM;Fink GR;Calhoun VD;Rost NS;Grefkes C
通讯作者：
Grefkes C
急性缺血性中风后的结果与性别特异性病变模式有关。
影响因子：
16.6
作者：
Bonkhoff AK;Schirmer MD;Bretzner M;Hong S;Regenhardt RW;Brudfors M;Donahue KL;Nardin MJ;Dalca AV;Giese AK;Etherton MR;Hancock BL;Mocking SJT;McIntosh EC;Attia J;Benavente OR;Bevan S;Cole JW;Donatti A;Griessenauer CJ;Heitsch L;Holmegaard L;Jood K;Jimenez-Conde J;Kittner SJ;Lemmens R;Levi CR;McDonough CW;Meschia JF;Phuah CL;Rolfs A;Ropele S;Rosand J;Roquer J;Rundek T;Sacco RL;Schmidt R;Sharma P;Slowik A;Söderholm M;Sousa A;Stanne TM;Strbian D;Tatlisumak T;Thijs V;Vagal A;Wasselius J;Woo D;Zand R;McArdle PF;Worrall BB;Jern C;Lindgren AG;Maguire J;Bzdok D;Wu O;MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium;Rost NS
通讯作者：
Rost NS
影响因子：
9.9
作者：
Erler, Kimberly S.;Wu, Rui;Lin, David J.
通讯作者：
Lin, David J.
影响因子：
3.5
作者：
Abraham A;Pedregosa F;Eickenberg M;Gervais P;Mueller A;Kossaifi J;Gramfort A;Thirion B;Varoquaux G
通讯作者：
Varoquaux G
DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Crossley, Nicolas A.;Mechelli, Andrea;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.