Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
Outcome after acute ischemic stroke is linked to sex-specific lesion patterns.
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急性缺血性中风后的结果与性别特异性病变模式有关。
DOI：
10.1038/s41467-021-23492-3
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发表时间：
2021-06-02
影响因子：
16.6
通讯作者：
Rost NS
中科院分区：
文献类型：
--
作者：
Bonkhoff AK;Schirmer MD;Bretzner M;Hong S;Regenhardt RW;Brudfors M;Donahue KL;Nardin MJ;Dalca AV;Giese AK;Etherton MR;Hancock BL;Mocking SJT;McIntosh EC;Attia J;Benavente OR;Bevan S;Cole JW;Donatti A;Griessenauer CJ;Heitsch L;Holmegaard L;Jood K;Jimenez-Conde J;Kittner SJ;Lemmens R;Levi CR;McDonough CW;Meschia JF;Phuah CL;Rolfs A;Ropele S;Rosand J;Roquer J;Rundek T;Sacco RL;Schmidt R;Sharma P;Slowik A;Söderholm M;Sousa A;Stanne TM;Strbian D;Tatlisumak T;Thijs V;Vagal A;Wasselius J;Woo D;Zand R;McArdle PF;Worrall BB;Jern C;Lindgren AG;Maguire J;Bzdok D;Wu O;MRI-GENIE and GISCOME Investigators and the International Stroke Genetics Consortium;Rost NS
急性缺血性中风对男性和女性的影响不同。特别是，女性经常报告经历比男性更严重的急性中风。我们推导出解剖学卒中病变的低维表示，并设计了贝叶斯分层建模框架，用于估计与急性卒中严重程度相关的病变模式中可能的性别差异（美国国立卫生研究院卒中量表）。该框架在555名患者（38%女性）中开发。结果在一个独立队列中得到验证（n = 503，41%为女性）。在这里，我们发现运动和语言功能的大脑损伤有助于解释男性和女性中风的严重程度，但更广泛的损伤模式与女性患者有关。女性卒中严重程度较高，与后循环附近的左半球病变相关，而男性无此相关性。我们的研究结果表明，有性别特异性的脑功能不对称性，可能是重要的性别分层的方法来管理急性缺血性中风的未来调查。急性缺血性中风对男性和女性的影响不同。在这里，作者展示了男性和女性不同的病变模式与中风严重程度的关系。
Acute ischemic stroke affects men and women differently. In particular, women are often reported to experience higher acute stroke severity than men. We derived a low-dimensional representation of anatomical stroke lesions and designed a Bayesian hierarchical modeling framework tailored to estimate possible sex differences in lesion patterns linked to acute stroke severity (National Institute of Health Stroke Scale). This framework was developed in 555 patients (38% female). Findings were validated in an independent cohort (n = 503, 41% female). Here, we show brain lesions in regions subserving motor and language functions help explain stroke severity in both men and women, however more widespread lesion patterns are relevant in female patients. Higher stroke severity in women, but not men, is associated with left hemisphere lesions in the vicinity of the posterior circulation. Our results suggest there are sex-specific functional cerebral asymmetries that may be important for future investigations of sex-stratified approaches to management of acute ischemic stroke. Acute ischemic stroke impacts men and women differently. Here, the authors show how different lesion patterns in men and women are linked to the extent of stroke severity.
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影响因子：
3.5
作者：
Abraham A;Pedregosa F;Eickenberg M;Gervais P;Mueller A;Kossaifi J;Gramfort A;Thirion B;Varoquaux G
通讯作者：
Varoquaux G
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作者：
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通讯作者：
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影响因子：
2.3
作者：
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
Rapp PR