Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.
Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.
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DOI：
10.1016/j.exppara.2010.02.002
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发表时间：
2010-07
影响因子：
2.1
通讯作者：
Teixeira, Antonio Lucio
中科院分区：
文献类型：
--
作者：
Lacerda-Queiroz, Norinne;Rodrigues, David Henrique;Vilela, Marcia Carvalho;de Miranda, Aline Silva;Guerra Amaral, Debora Cristina;da Silva Camargos, Elizabeth Ribeiro;de Moura Carvalho, Leonardo Jose;Howe, Charles L.;Teixeira, Mauro Martins;Teixeira, Antonio Lucio
实验性脑疟疾是一种由宿主对寄生虫的免疫反应引起的神经炎症。本研究利用活体显微镜研究了伯氏疟原虫（ANKA）感染C57Bl/6小鼠脑微循环中白细胞的募集及其与行为变化的时间关系。我们发现白细胞募集从感染后第5天开始增加。还观察到组织病理学变化和大脑炎症细胞因子水平升高。SHIRPA方案评估的行为表现显示从第6天起功能受损。因此，早期白细胞迁移到大脑和相关的炎症变化可能参与寄生虫感染C57Bl/6小鼠的神经损伤。
Experimental cerebral malaria is a neuroinflammatory condition that results from the host immune response to the parasite. Using intravital microscopy, we investigated leukocyte recruitment in the brain microcirculation and the temporal relationship of this process to the behavioral changes observed in Plasmodium berghei (strain ANKA)-infected C57Bl/6 mice. We found that leukocyte recruitment was increased from day 5 post-infection (p.i.) onwards. Histopathological changes and increased levels of inflammatory cytokines in the brain were also observed. Behavioral performance evaluated by the SHIRPA protocol showed functional impairment from day 6 p.i. onwards. Thus, early leukocyte migration into the brain and associated inflammatory changes may be involved in neurological impairment in parasite-infected C57Bl/6 mice.
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影响因子：
5
作者：
Andrea Cutrullis, Romina;Postan, Miriam;Santiago Corral, Ricardo
通讯作者：
Santiago Corral, Ricardo
DOI：
10.4269/ajtmh.2008.78.198
发表时间：
2008-02-01
影响因子：
3.3
作者：
John, Chandy C.;Panoskaltsis-Mortari, Angela;Boivin, Michael J.
通讯作者：
Boivin, Michael J.
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4.4
作者：
Belnoue, E;Kayibanda, M;Rénia, L
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Rénia, L
影响因子：
5
作者：
Lackner, P;Beer, R;Schmutzhard, E
通讯作者：
Schmutzhard, E
DOI：
10.1111/j.1365-2613.2008.00622.x
发表时间：
2009-04-01
影响因子：
3
作者：
Martins, Yuri Chaves;Smith, Mary Jane;de Moura Carvalho, Leonardo Jose
通讯作者：
de Moura Carvalho, Leonardo Jose