Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants.
Direct comparison of a dietary portfolio of cholesterol-lowering foods with a statin in hypercholesterolemic participants.
复制标题
在高胆固醇血症参与者中直接比较降胆固醇食物与他汀类药物的饮食组合。
DOI：
--
复制
发表时间：
2005
影响因子：
7.1
通讯作者：
P. Connelly
中科院分区：
文献类型：
--
作者：
D. Jenkins;C. Kendall;A. Marchie;D. Faulkner;J. Wong;R. D. de Souza;A. Emam;T. Parker;E. Vidgen;E. Trautwein;K. Lapsley;R. Josse;Lawrence A Leiter;W. Singer;P. Connelly
背景
3-羟基-3-甲基-戊二酰辅酶 A (HMG-CoA) 还原酶抑制剂可降低血清胆固醇，并且越来越多地提倡在一级预防中使用，以实现低密度脂蛋白胆固醇的降低。结合降胆固醇食物的新饮食方法可能提供另一种选择，但这些方法尚未在同一个人中与他汀类药物进行直接比较。
目标
目的是在同一受试者中比较饮食组合与他汀类药物降低胆固醇的潜力。
设计
34 名高脂血症参与者作为门诊患者随机接受了所有三种 1 个月治疗：极低饱和脂肪饮食（对照饮食）、相同饮食加 20 毫克洛伐他汀（他汀类饮食）、高植物甾醇饮食（1.0 克/1000 kcal）、大豆蛋白食品（包括豆奶和大豆汉堡，21.4 g/1000 kcal）、杏仁（14 克/1000 kcal），以及来自燕麦、大麦、洋车前子以及蔬菜秋葵和茄子的粘性纤维（10 g/1000 kcal）（组合饮食）。在第 0、2 和 4 周时采集空腹血样。
结果
对照组、他汀类药物和组合饮食 4 周后，LDL 胆固醇浓度分别降低了 8.5+/-1.9%、33.3+/-1.9% 和 29.6+/-1.3%。尽管他汀类药物和组合治疗之间的绝对差异在 4 周时显着 (P=0.013)，但 9 名参与者 (26%) 通过组合饮食达到了最低的 LDL 胆固醇浓度。此外，他汀类药物 (n=27) 和组合饮食 (n=24) 将 LDL 胆固醇降低至 3.4 mmol/L 一级预防临界值以下的能力没有显着差异 (P=0.288)。
结论
在实现当前一级预防的血脂目标方面，膳食组合可能与第一代他汀类药物的效力没有差异。因此，它们可能会弥补当前治疗饮食和新型他汀类药物之间的治疗差距。
BACKGROUND
3-Hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors reduce serum cholesterol and are increasingly advocated in primary prevention to achieve reductions in LDL cholesterol. Newer dietary approaches combining cholesterol-lowering foods may offer another option, but these approaches have not been compared directly with statins in the same persons.
OBJECTIVE
The objective was to compare, in the same subjects, the cholesterol-lowering potential of a dietary portfolio with that of a statin.
DESIGN
Thirty-four hyperlipidemic participants underwent all three 1-mo treatments in random order as outpatients: a very-low-saturated-fat diet (control diet), the same diet plus 20 mg lovastatin (statin diet), and a diet high in plant sterols (1.0 g/1000 kcal), soy-protein foods (including soy milks and soy burgers, 21.4 g/1000 kcal), almonds (14 g/1000 kcal), and viscous fibers from oats, barley, psyllium, and the vegetables okra and eggplant (10 g/1000 kcal) (portfolio diets). Fasting blood samples were obtained at 0, 2, and 4 wk.
RESULTS
LDL-cholesterol concentrations decreased by 8.5+/-1.9%, 33.3+/-1.9%, and 29.6+/-1.3% after 4 wk of the control, statin, and portfolio diets, respectively. Although the absolute difference between the statin and the portfolio treatments was significant at 4 wk (P=0.013), 9 participants (26%) achieved their lowest LDL-cholesterol concentrations with the portfolio diet. Moreover, the statin (n=27) and the portfolio (n=24) diets did not differ significantly (P=0.288) in their ability to reduce LDL cholesterol below the 3.4-mmol/L primary prevention cutoff.
CONCLUSIONS
Dietary combinations may not differ in potency from first-generation statins in achieving current lipid goals for primary prevention. They may, therefore, bridge the treatment gap between current therapeutic diets and newer statins.
影响因子：
158.5
作者：
GRUNDY, SM
通讯作者：
GRUNDY, SM
影响因子：
120.7
作者：
Ornish, D;Scherwitz, LW;Brand, RJ
通讯作者：
Brand, RJ