Getting folded: chaperone proteins in muscle development, maintenance and disease.
Getting folded: chaperone proteins in muscle development, maintenance and disease.
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DOI：
10.1002/ar.22980
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发表时间：
2014-09
影响因子：
2
通讯作者：
Bernstein, Sanford I.
中科院分区：
文献类型：
--
作者：
Smith, Daniel A.;Carland, Carmen R.;Guo, Yiming;Bernstein, Sanford I.
Chaperone proteins are critical for protein folding and stability, and hence are necessary for normal cellular organization and function. Recent studies have begun to interrogate the role of this specialized class of proteins in muscle biology. During development, chaperone-mediated folding of client proteins enables their integration into nascent sarcomeres. In addition to assisting with muscle differentiation, chaperones play a key role in maintenance of muscle tissues. Further, disruption of the chaperone network can result in neuromuscular disease. In this review, we discuss how chaperones are involved in myofibrillogenesis, sarcomere maintenance and muscle disorders. We also consider the possibilities of therapeutically targeting chaperones to treat muscle disease.
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