Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder.

Capacity to delay reward differentiates obsessive-compulsive disorder and obsessive-compulsive personality disorder.
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DOI:
10.1016/j.biopsych.2013.09.007
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发表时间:
2014-04-15
影响因子:
10.6
通讯作者:
Simpson, H. Blair
Simpson, H. Blair
中科院分区:
医学1区
文献类型:
--
作者:
Pinto, Anthony;Steinglass, Joanna E.;Greene, Ashley L.;Weber, Elke U.;Simpson, H. Blair

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尽管强迫症(OCD)和强迫性人格障碍(OCPD)之间的关系长期以来一直存在争议,但从未对OCD(无OCPD)和OCPD(无OCD)的临床样本进行系统比较。我们研究了强迫症、强迫症或两者兼有的个体在症状、功能和自我控制措施(延迟奖励的能力)方面是否存在差异。 25 名 OCD、25 名 OCPD、25 名共病 OCD+OCPD 和 25 名健康对照 (HC) 完成了临床评估和经过验证的跨期选择任务,该任务衡量放弃小的即时奖励以获取更大的延迟奖励的能力。强迫症和强迫症受试者均表现出心理社会功能和生活质量以及强迫行为的损害,但只有强迫症受试者报告了强迫行为。患有 OCPD 的个体,无论有或没有合并强迫症,对延迟金钱奖励的价值的折扣明显低于强迫症和 HC。这种过度延迟奖励的能力将强迫症与强迫症区分开来,并且与完美主义和僵化有关。 OCD 和 OCPD 都是以强迫行为为特征的损害性疾病,但可以通过 OCD 中存在强迫观念和 OCPD 中延迟奖赏的过度能力来区分它们。患有强迫症的个体表现出较少的时间折扣(暗示过度的自我控制),而先前的研究表明,患有物质使用障碍的个体表现出更大的折扣(暗示冲动)支持这样一个前提,即自我控制的这一组成部分存在于一个连续体中,其中两个极端(冲动和过度控制)都会导致精神病理学。
Although the relationship between obsessive compulsive disorder (OCD) and obsessive compulsive personality disorder (OCPD) has long been debated, clinical samples of OCD (without OCPD) and OCPD (without OCD) have never been systematically compared. We studied whether individuals with OCD, OCPD, or both conditions differ on symptomatology, functioning, and a measure of self-control: the capacity to delay reward. 25 OCD, 25 OCPD, 25 comorbid OCD+OCPD, and 25 healthy controls (HC) completed clinical assessments and a validated intertemporal choice task that measures capacity to forego small immediate rewards for larger delayed rewards. OCD and OCPD subjects both showed impairment in psychosocial functioning and quality of life, as well as compulsive behavior, but only subjects with OCD reported obsessions. Individuals with OCPD, with or without comorbid OCD, discounted the value of delayed monetary rewards significantly less than OCD and HC. This excessive capacity to delay reward discriminates OCPD from OCD, and is associated with perfectionism and rigidity. OCD and OCPD are both impairing disorders marked by compulsive behaviors, but they can be differentiated by the presence of obsessions in OCD and by excessive capacity to delay reward in OCPD. That individuals with OCPD show less temporal discounting (suggestive of excessive self-control) whereas prior studies have shown that individuals with substance use disorders show greater discounting (suggestive of impulsivity) supports the premise that this component of self-control lies on a continuum in which both extremes (impulsivity and overcontrol) contribute to psychopathology.
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