Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis.
Association Between Psychosocial Disorders and Gastroesophageal Reflux Disease: A Systematic Review and Meta-analysis.
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DOI：
10.5056/jnm21044
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发表时间：
2022-04-30
影响因子：
3.4
通讯作者：
Bai G
中科院分区：
文献类型：
--
作者：
He M;Wang Q;Yao D;Li J;Bai G
胃食管反流病（GERD）的发病率逐年上升。研究表明，心理社会障碍可能与GERD的发展有关。然而，评估心理社会障碍和GERD之间关系的研究并不一致。因此，我们对评估心理社会障碍与GERD之间关系的观察性研究进行了系统回顾和荟萃分析。我们系统检索了PubMed、Embase、科克伦和Web of Science数据库，直至2020年10月17日。使用随机效应模型计算合并OR和95% CI以及亚组分析。进行亚组分析，以确定异质性的来源。通过一项研究删除的敏感性分析被用来测试我们的结果的鲁棒性。这项荟萃分析包括来自9项研究的1485268名参与者。以心理社会障碍为结局的研究显示，GERD患者的心理社会障碍发生率高于非GERD患者（OR，2.57; 95% CI，1.87-3.54; I2 = 93.8%; P < 0.001）。以GERD作为结局的研究显示，心理社会障碍与GERD风险增加相关（OR，2.23; 95%CI，1.42-3.51; I2 = 97.1%; P < 0.001）。亚组分析结果显示，非糜烂性反流病组的焦虑风险高于糜烂性反流病组（OR，9.45; 95% CI，5.54-16.13; I2 = 12.6%; P = 0.285）。我们的荟萃分析结果显示，心理社会障碍与GERD相关;两者之间存在相互作用。
The incidence of gastroesophageal reflux disease (GERD) is increasing annually. Studies have suggested that psychosocial disorders may be linked to the development of GERD. However, studies evaluating the association between psychosocial disorders and GERD have been inconsistent. Thus, we conducted a systematic review and meta-analysis of observational studies that evaluated the association between psychosocial disorders and GERD. We systematically searched the PubMed, Embase, Cochrane, and Web of Science databases until October 17, 2020. Pooled OR with 95% CI and subgroup analyses were calculated using a random-effects model. Subgroup analyses were performed to identify the sources of heterogeneity. Sensitivity analysis by one-study removal was used to test the robustness of our results. This meta-analysis included 1 485 268 participants from 9 studies. Studies using psychosocial disorders as the outcome showed that patients with GERD had a higher incidence of psychosocial disorders compared to that in patients without GERD (OR, 2.57; 95% CI, 1.87-3.54; I2 = 93.8%; P < 0.001). Studies using GERD as an outcome showed an association between psychosocial disorders and an increased risk of GERD (OR, 2.23; 95% CI, 1.42-3.51; I2 = 97.1%; P < 0.001). The results of the subgroup analysis showed that the non-erosive reflux disease group had a higher increased risk of anxiety than erosive reflux disease group (OR, 9.45; 95% CI, 5.54-16.13; I2 = 12.6%; P = 0.285). Results of our meta-analysis showed that psychosocial disorders are associated with GERD; there is an interaction between the two.
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影响因子：
3.4
作者：
Kim SE;Kim N;Oh S;Kim HM;Park MI;Lee DH;Jung HC
通讯作者：
Jung HC
影响因子：
3.1
作者：
Andrade, L;Caraveo-Anduaga, JJ;Wittchen, HU
通讯作者：
Wittchen, HU
DOI：
10.1007/978-981-32-9705-0_28
发表时间：
2020-01-01
期刊：
ANXIETY DISORDERS: RETHINKING AND UNDERSTANDING RECENT DISCOVERIES
影响因子：
--
作者：
Andreescu, Carmen;Lee, Soyoung
通讯作者：
Lee, Soyoung
影响因子：
4.3
作者：
Ang, Tiing-Leong;Fock, Kwong-Ming;Tan, Jessica
通讯作者：
Tan, Jessica
影响因子：
4.6
作者：
Kim SY;Kim HJ;Lim H;Kong IG;Kim M;Choi HG
通讯作者：
Choi HG