Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort.
Bidirectional association between gastroesophageal reflux disease and depression: Two different nested case-control studies using a national sample cohort.
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DOI：
10.1038/s41598-018-29629-7
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发表时间：
2018-08-06
影响因子：
4.6
通讯作者：
Choi HG
中科院分区：
文献类型：
--
作者：
Kim SY;Kim HJ;Lim H;Kong IG;Kim M;Choi HG
本研究的目的是评估胃食管反流病（GERD）和抑郁症之间的关系，使用韩国人口的国家样本队列。数据收集自2002年至2013年韩国国民健康保险服务-国家样本队列中≥20岁的个体。我们设计了两个不同的嵌套病例对照研究。在研究I中，60，957名抑郁症患者与243，828名对照者以1：4的比例匹配，并分析了他们先前的GERD病史。在研究II中，133，089名GERD参与者与266，178名对照者以1：2的比例匹配，并分析了他们以前的抑郁史。采用非条件logistic回归分析分析粗比值比和校正比值比（OR），并计算95%置信区间（CI）。根据年龄和性别进行亚组分析。在抑郁症患者中，GERD的校正OR为2.01（95% CI = 1.96-2.07）（研究I）。GERD患者中抑郁的校正OR为1.48（95% CI = 1.43-1.52）（研究II）。亚组分析的结果是一致的。GERD和抑郁症表现出双向关联。
The purpose of this study is to evaluate the associations between gastroesophageal reflux disease (GERD) and depression using a national sample cohort of the Korean population. Data were collected from individuals ≥20 years old in the Korean National Health Insurance Service-National Sample Cohort between 2002 and 2013. We designed two different nested case-control studies. In study I, 60,957 participants with depression were matched at a 1:4 ratio with 243,828 controls, and their previous histories of GERD were analyzed. In study II, 133,089 participants with GERD were matched at a 1:2 ratio with 266,178 controls, and their previous histories of depression were analyzed. Crude and adjusted odds ratios (ORs) were analyzed using unconditional logistic regression analyses, and 95% confidence intervals (CIs) were calculated. Subgroup analyses were performed according to age and sex. The adjusted OR for GERD was 2.01 (95% CI = 1.96–2.07) in the patients with depression (study I). The adjusted OR for depression was 1.48 (95% CI = 1.43–1.52) in the patients with GERD (study II). The results of the subgroup analyses were consistent. GERD and depression displayed bidirectional associations.
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