Functional and antigenic maps in the rat cerebellum: Zebrin compartmentation and vibrissal receptive fields in lobule IXa
Functional and antigenic maps in the rat cerebellum: Zebrin compartmentation and vibrissal receptive fields in lobule IXa
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大鼠小脑的功能和抗原图谱：小叶 IXa 中的 Zebrin 区室和触须感受野
DOI：
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
R. Hawkes
中科院分区：
文献类型：
--
作者：
Vijay Chockkan;R. Hawkes
哺乳动物的小脑在结构上和生物化学上都被划分成一系列的矢状面旁带。在成年大鼠，用抗斑马素II单抗对浦肯野细胞亚群进行免疫细胞化学染色可显示条带。与斑马素II分布所显示的条带不同，触觉表征的电生理图谱显示了一个明显不同的组织，即交织在一起的小接受野的拼接体视。我们比较了斑马素II的区隔和小叶IXa背面的振动感受场的分布。对9只成年大鼠进行了研究。Zebrin II免疫细胞化学显示中线(P1+)有一条Zebrin II+带，其他三条带(P2+，P3+，P4+)呈侧向排列，由未染色的浦肯野细胞的P1−、P2−和P3−带隔开。变异的唯一重要来源是P3−有时定义不清，使得P3+和P4+很难区分。小叶IXa颗粒层的电生理记录发现，中线两侧各有两个可复制的触觉感受野(V1和V2)，偶尔还可识别出第三个较外侧的触觉感受野(V3)。当构建感受野图谱并与相同个体的Zebrin II隔室图谱比对时，V1感受野位于P1−，V2位于P2−，V3位于P3−。然而，感受场通常从P−带延伸到相邻的P+带到每一侧。因此，在小叶IXa中有一种简单的、可重复的触觉感受场组织，它与Zebrin II免疫细胞化学显示的浦肯野细胞分区有恒定的关系。大脑皮层的生化分离可能有助于组织传入和传出的投射地形图，从而使小脑的感觉和运动图对齐。©1994 Wiley-Liss，Inc.
The mammalian cerebellum is compartmentalized, both structurally and biochemically, into an array of parasagittal bands. In the adult rat, bands can be shown by immunocytochemical staining of a Purkinje cell subset with the monoclonal antibody antizebrin II. In contrast to the bands revealed by the zebrin II distribution, electrophysiological maps of tactile representations show an apparently quite different organization, a patchwork somatotopy of interwoven small receptive fields. We have compared zebrin II compartmentation with the distribution of vibrissal receptive fields in the dorsal face of lobule IXa. Nine adult rats were studied. Zebrin II immunocytochemistry revealed a zebrin II+ band at the midline (P1+) and three others (P2+, P3+, P4+) arrayed laterally, separated by the P1−, P2−, and P3− bands of unstained Purkinje cells. The only significant source of variability was that P3− was sometimes ill defined, making the P3+ and P4+ difficult to distinguish. Electrophysiological recording in the granular layer of lobule IXa identified two reproducible vibrissal receptive fields on each side of the midline (V1 and V2), with a third, more laterally, identified occasionally (V3). When receptive field maps were constructed and aligned with the zebrin II compartment maps from the same individuals, the V1 receptive field was centered on P1−, V2 on P2−, and V3 on P3−. However, the receptive fields typically extended beyond the P− band into the neighboring P+ to each side. Thus there is a simple, reproducible vibrissal receptive field organization in lobule IXa that bears a constant relationship to the Purkinje cell compartmentation revealed by zebrin II immunocytochemistry. The biochemical parcellation of the cortex may serve to organize the afferent and efferent projection topography and thus to align the sensory and motor maps in the cerebellum. © 1994 Wiley‐Liss, Inc.
矢状排列的浦肯野细胞在扰动运动过程中的反应：攀爬纤维激活与简单尖峰调制的关系。
影响因子：
2.5
作者：
Lou,JS;Bloedel,JR
通讯作者：
Bloedel,JR