Epigenetic mechanisms in migraine: a promising avenue?
Epigenetic mechanisms in migraine: a promising avenue?
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DOI：
10.1186/1741-7015-11-26
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发表时间：
2013-02-04
期刊：
影响因子：
9.3
通讯作者：
Ferrari MD
中科院分区：
文献类型：
--
作者：
Eising E;A Datson N;van den Maagdenberg AM;Ferrari MD
偏头痛是一种常见的致残性脑部疾病，其典型特征是严重头痛的发作，并伴有自主神经和神经症状。其病因远未解决。这篇综述将集中于表观遗传机制在疾病病因学中发挥重要作用的证据。表观遗传学包括DNA甲基化和组蛋白尾部的翻译后修饰，影响染色质结构和基因表达。除了在建立细胞和发育阶段特异性的基因表达调控中发挥作用外，表观遗传过程对于编程持久的细胞对环境信号的反应也很重要。表观遗传机制可以解释非遗传的内源性和外源性因素，如女性性激素，应激激素和炎症触发因子如何调节发作频率。开发专门针对表观遗传机制的药物可能会为偏头痛的预防性治疗开辟令人兴奋的新途径。
Migraine is a disabling common brain disorder typically characterized by attacks of severe headache and associated with autonomic and neurological symptoms. Its etiology is far from resolved. This review will focus on evidence that epigenetic mechanisms play an important role in disease etiology. Epigenetics comprise both DNA methylation and post-translational modifications of the tails of histone proteins, affecting chromatin structure and gene expression. Besides playing a role in establishing cellular and developmental stage-specific regulation of gene expression, epigenetic processes are also important for programming lasting cellular responses to environmental signals. Epigenetic mechanisms may explain how non-genetic endogenous and exogenous factors such as female sex hormones, stress hormones and inflammation trigger may modulate attack frequency. Developing drugs that specifically target epigenetic mechanisms may open up exciting new avenues for the prophylactic treatment of migraine.
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DOI：
10.1097/01.wcb.0000126566.34753.30
发表时间：
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影响因子：
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