Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission.
Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission.
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DOI：
10.1016/j.nlm.2011.02.015
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发表时间：
2011-07
影响因子：
2.7
通讯作者：
Monteggia, Lisa M.
中科院分区：
文献类型：
--
作者：
Nelson, Erika D.;Monteggia, Lisa M.
在哺乳动物发育过程中，表观遗传机制在控制基因表达中的作用已经得到了很好的证实。特定DNA或组蛋白修饰与许多神经发育和神经退行性疾病之间的关联意味着发育和成熟大脑中表观遗传失调的显著后果，后者是本综述的总体重点。越来越多的证据表明，除了神经和精神疾病外，表观遗传变化还涉及正常的认知过程。最近对成人大脑中表观遗传修饰调控的研究揭示了控制学习和记忆相关行为以及长期突触可塑性的新颖而令人惊讶的动态机制。DNA甲基化和组蛋白乙酰化也与基础突触传递的调节以及大脑各区域兴奋和抑制之间的平衡有关。研究已经开始揭示基因表达的一些变化，这些变化似乎介导了许多这些影响，但对所涉及的精确机制的理解仍然缺乏。然而，影响神经元活动的表观遗传过程的根本重要性正变得越来越明显。
The role of epigenetic mechanisms in control of gene expression during mammalian development is well established. Associations between specific DNA or histone modifications and numerous neurodevelopmental and neurodegenerative disorders implies significant consequences of epigenetic dysregulation in both the developing and mature brain, the latter of which is the general focus of this review. Accumulating evidence suggests that epigenetic changes are involved in normal cognitive processes in addition to neurological and psychiatric disorders. Recent investigations into the regulation of epigenetic modifications in the adult brain have revealed novel and surprisingly dynamic mechanisms for controlling learning and memory-related behaviors as well as long-term synaptic plasticity. DNA methylation and histone acetylation have also been implicated in the modulation of basal synaptic transmission and the balance between excitation and inhibition in various brain regions. Studies have begun to uncover some of the alterations in gene expression that appear to mediate many of these effects, but an understanding of the precise mechanisms involved is still lacking. Nevertheless, the fundamental importance of epigenetic processes in influencing neuronal activity is becoming increasingly evident.
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DOI：
10.1523/jneurosci.0097-09.2009
发表时间：
2009-06-24
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Akhtar MW;Raingo J;Nelson ED;Montgomery RL;Olson EN;Kavalali ET;Monteggia LM
通讯作者：
Monteggia LM
影响因子：
3.7
作者：
Crepaldi, Luca;Riccio, Antonella
通讯作者：
Riccio, Antonella
Dnmt1 和 Dnmt3a 维持 DNA 甲基化并调节成人前脑神经元的突触功能
影响因子：
25
作者：
Feng, Jian;Zhou, Yu;Campbell, Susan L.;Le, Thuc;Li, En;Sweatt, J. David;Silva, Alcino J.;Fan, Guoping
通讯作者：
Fan, Guoping
影响因子：
6.1
作者：
Asaka, Y;Jugloff, DGM;Fitzsimonds, RM
通讯作者：
Fitzsimonds, RM
DOI：
10.1073/pnas.1834280100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Bourtchouladze, R;Lidge, R;Tully, T
通讯作者：
Tully, T