bNAber: database of broadly neutralizing HIV antibodies.
bNAber: database of broadly neutralizing HIV antibodies.
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DOI：
10.1093/nar/gkt1083
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发表时间：
2014-01
影响因子：
14.9
通讯作者：
Godzik A
中科院分区：
文献类型：
--
作者：
Eroshkin AM;LeBlanc A;Weekes D;Post K;Li Z;Rajput A;Butera ST;Burton DR;Godzik A
广泛中和抗体（bNAb）的发现为HIV疫苗研究和整个免疫学提供了巨大的推动力。http://bNAber.org上的bNAber数据库提供了对快速增长的HIV bNAb清单的详细数据的开放的、用户友好的访问，包括中和谱、序列和三维结构（如可用）。它还提供了广泛的可视化和分析工具列表，例如用于分析中和数据的热图以及用于将bNAb特性与单个抗体的结构和序列特征相关联的结构和序列查看器。bNAber数据库的目标是使该领域的研究人员能够轻松地比较和分析关于bNAb的现有信息，从而支持设计有效的艾滋病毒/艾滋病疫苗的努力。bNAber数据库不仅提供了对目前分散在个别论文的补充材料部分的数据的轻松访问，而且还有助于开发必须与新bNAb的发现一起呈现的数据的通用标准以及如何共享这些数据的通用机制。
The discovery of broadly neutralizing antibodies (bNAbs) has provided an enormous impetus to the HIV vaccine research and to entire immunology. The bNAber database at http://bNAber.org provides open, user-friendly access to detailed data on the rapidly growing list of HIV bNAbs, including neutralization profiles, sequences and three-dimensional structures (when available). It also provides an extensive list of visualization and analysis tools, such as heatmaps to analyse neutralization data as well as structure and sequence viewers to correlate bNAbs properties with structural and sequence features of individual antibodies. The goal of the bNAber database is to enable researchers in this field to easily compare and analyse available information on bNAbs thereby supporting efforts to design an effective vaccine for HIV/AIDS. The bNAber database not only provides easy access to data that currently is scattered in the Supplementary Materials sections of individual papers, but also contributes to the development of general standards of data that have to be presented with the discovery of new bNAbs and a universal mechanism of how such data can be shared.
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DOI：
10.1126/science.1178746
发表时间：
2009-10-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Walker LM;Phogat SK;Chan-Hui PY;Wagner D;Phung P;Goss JL;Wrin T;Simek MD;Fling S;Mitcham JL;Lehrman JK;Priddy FH;Olsen OA;Frey SM;Hammond PW;Protocol G Principal Investigators;Kaminsky S;Zamb T;Moyle M;Koff WC;Poignard P;Burton DR
通讯作者：
Burton DR
影响因子：
64.8
作者：
Huang J;Ofek G;Laub L;Louder MK;Doria-Rose NA;Longo NS;Imamichi H;Bailer RT;Chakrabarti B;Sharma SK;Alam SM;Wang T;Yang Y;Zhang B;Migueles SA;Wyatt R;Haynes BF;Kwong PD;Mascola JR;Connors M
通讯作者：
Connors M
影响因子：
5.8
作者：
Waterhouse, Andrew M.;Procter, James B.;Barton, Geoffrey J.
通讯作者：
Barton, Geoffrey J.
影响因子：
5.8
作者：
Ye, YZ;Godzik, A
通讯作者：
Godzik, A
DOI：
10.1126/science.1213782
发表时间：
2011-12-02
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Diskin R;Scheid JF;Marcovecchio PM;West AP Jr;Klein F;Gao H;Gnanapragasam PN;Abadir A;Seaman MS;Nussenzweig MC;Bjorkman PJ
通讯作者：
Bjorkman PJ