Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.
Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.
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DOI:
10.1016/j.diagmicrobio.2021.115534
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发表时间:
2021-12
影响因子:
2.9
通讯作者:
Nauen, David W.
中科院分区:
文献类型:
--
作者:
Butcher, Monica;Puiu, Daniela;Romagnoli, Mark;Carroll, Karen C.;Salzberg, Steven L.;Nauen, David W.
Bloodstream infection with Bacillus cereus/thuringiensis can be life threatening, particularly in patients who are severely immunocompromised. In this report we describe a case that progressed from asymptomatic to fatal over approximately 5 hours despite extensive resuscitation efforts. We identify the pathogen and assemble its genome, in which we find genes for toxins that may have contributed to the precipitous demise. In the context of this and other cases we discuss the possible indication for rapid appropriate antibiotic administration and potentially antitoxin treatment or toxin removal in fulminant illness in immunocompromised patients.
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影响因子:
2.2
作者:
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通讯作者:
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影响因子:
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发表时间:
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通讯作者:
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