Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.

Rapidly fatal infection with Bacillus cereus/thuringiensis: genome assembly of the responsible pathogen and consideration of possibly contributing toxins.
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DOI:
10.1016/j.diagmicrobio.2021.115534
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发表时间:
2021-12
影响因子:
2.9
通讯作者:
Nauen, David W.
Nauen, David W.
中科院分区:
医学4区
文献类型:
--
作者:
Butcher, Monica;Puiu, Daniela;Romagnoli, Mark;Carroll, Karen C.;Salzberg, Steven L.;Nauen, David W.

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蜡状芽孢杆菌/苏云金芽孢杆菌的血流感染可危及生命,特别是在严重免疫功能低下的患者中。在这份报告中,我们描述了一个病例,尽管进行了广泛的复苏努力,但在大约5小时内从无症状发展为致命。我们确定了病原体并组装了它的基因组,在其中我们发现了可能导致这种突然死亡的毒素基因。在这种和其他情况下,我们讨论了可能的适应症,快速适当的抗生素管理和潜在的抗毒素治疗或毒素清除暴发性疾病的免疫功能低下的患者。
Bloodstream infection with Bacillus cereus/thuringiensis can be life threatening, particularly in patients who are severely immunocompromised. In this report we describe a case that progressed from asymptomatic to fatal over approximately 5 hours despite extensive resuscitation efforts. We identify the pathogen and assemble its genome, in which we find genes for toxins that may have contributed to the precipitous demise. In the context of this and other cases we discuss the possible indication for rapid appropriate antibiotic administration and potentially antitoxin treatment or toxin removal in fulminant illness in immunocompromised patients.
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