Electrochemical patterning and detection of DNA arrays on a two-electrode platform.
Electrochemical patterning and detection of DNA arrays on a two-electrode platform.
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DOI：
10.1021/ja410902j
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发表时间：
2013-12-26
影响因子：
15
通讯作者：
Barton JK
中科院分区：
文献类型：
--
作者：
Furst A;Landefeld S;Hill MG;Barton JK
我们报告了一种新的DNA阵列形成方法，该方法是电化学形成的，并用双电极平台进行寻址。用一个电极图案化的铜催化剂的电化学活化使得能够将多个DNA序列精确地放置到第二电极表面上。双电极图案化和检测平台允许图案化DNA阵列的空间分辨率和通过DNA介导的电荷传输与电催化的检测的优化。这种双电极平台已被用于形成阵列，使良好匹配和不匹配的序列之间的差异，TATA结合蛋白的检测，和序列选择性DNA杂交。
We report a novel method of DNA array formation that is electrochemically formed and addressed with a two-electrode platform. Electrochemical activation of a copper catalyst, patterned with one electrode, enables precise placement of multiple sequences of DNA onto a second electrode surface. The two-electrode patterning and detection platform allows for both spatial resolution of the patterned DNA array and optimization of detection through DNA-mediated charge transport with electrocatalysis. This two-electrode platform has been used to form arrays that enable differentiation between well-matched and mismatched sequences, the detection of TATA-binding protein, and sequence-selective DNA hybridization.
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影响因子：
15
作者：
Pheeney, Catrina G.;Arnold, Anna R.;Grodick, Michael A.;Barton, Jacqueline K.
通讯作者：
Barton, Jacqueline K.
影响因子：
4.7
作者：
Gorodetsky, Alon A.;Buzzeo, Marisa C.;Barton, Jacqueline K.
通讯作者：
Barton, Jacqueline K.
影响因子：
15
作者：
Devaraj, NK;Dinolfo, PH;Collman, JP
通讯作者：
Collman, JP
影响因子：
64.8
作者：
NIKOLOV, DB;HU, SH;BURLEY, SK
通讯作者：
BURLEY, SK
影响因子：
7.4
作者：
Zoski, Cynthia G.;Luman, Charles R.;Bard, Allen J.
通讯作者：
Bard, Allen J.