DNA-mediated electrochemistry.

DNA-mediated electrochemistry.
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DOI:
10.1021/bc8003149
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发表时间:
2008-12
影响因子:
4.7
通讯作者:
Barton, Jacqueline K.
Barton, Jacqueline K.
中科院分区:
化学2区
文献类型:
--
作者:
Gorodetsky, Alon A.;Buzzeo, Marisa C.;Barton, Jacqueline K.

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DNA的碱基对堆叠已被证明是溶液中和DNA修饰表面的长程电荷传输化学的介质。这种化学对碱基对堆叠中的结构扰动非常敏感,如病变、单碱基错配和蛋白质结合。我们已经利用这种灵敏度的发展可靠的电化学分析的基础上,在自组装DNA单层的DNA电荷传输。在这里,我们讨论了DNA介导的电化学的特点,应用和优势。
The base pair stack of DNA has been demonstrated as a medium for long range charge transport chemistry both in solution and at DNA-modified surfaces. This chemistry is exquisitely sensitive to structural perturbations in the base pair stack as occur with lesions, single base mismatches, and protein binding. We have exploited this sensitivity for the development of reliable electrochemical assays based on DNA charge transport at self-assembled DNA monolayers. Here we discuss the characteristic features, applications, and advantages of DNA-mediated electrochemistry.
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