Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
Consanguinity Rates Predict Long Runs of Homozygosity in Jewish Populations.
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DOI:
10.1159/000478897
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发表时间:
2016
期刊:
影响因子:
1.8
通讯作者:
Rosenberg NA
中科院分区:
文献类型:
--
作者:
Kang JTL;Goldberg A;Edge MD;Behar DM;Rosenberg NA
Recent studies have highlighted the potential of analyses of genomic sharing to produce insight into the demographic processes affecting human populations. We study ROH in 18 Jewish populations, examining these groups in relation to 123 non-Jewish populations sampled worldwide. By sorting ROH into three length classes—short, intermediate, and long—we evaluate the impact of demographic processes on genomic patterns in Jewish populations. We find that the portion of the genome appearing in long ROH—the length class most directly related to recent consanguinity—closely accords with data gathered from interviews during the 1950s on frequencies of consanguineous unions in various Jewish groups. A high correlation between 1950s consanguinity levels and coverage by long ROH explains differences across populations in ROH patterns. The dissection of ROH into length classes and the comparison to consanguinity data assist in understanding a number of additional phenomena, including similarities of Jewish populations to Middle Eastern, European, and Central and South Asian non-Jewish populations in short ROH patterns, relative lengths of identity-by-descent tracts in different Jewish groups, and the “population isolate” status of the Ashkenazi Jews.
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影响因子:
3.7
作者:
Kirin M;McQuillan R;Franklin CS;Campbell H;McKeigue PM;Wilson JF
通讯作者:
Wilson JF
影响因子:
2.9
作者:
Olshen, Adam B.;Gold, Bert;Boyd, Jeff
通讯作者:
Boyd, Jeff
影响因子:
3.5
作者:
Nothnagel, Michael;Lu, Timothy Tehua;Krawczak, Michael
通讯作者:
Krawczak, Michael
影响因子:
64.8
作者:
Joshi PK;Esko T;Mattsson H;Eklund N;Gandin I;Nutile T;Jackson AU;Schurmann C;Smith AV;Zhang W;Okada Y;Stančáková A;Faul JD;Zhao W;Bartz TM;Concas MP;Franceschini N;Enroth S;Vitart V;Trompet S;Guo X;Chasman DI;O'Connel JR;Corre T;Nongmaithem SS;Chen Y;Mangino M;Ruggiero D;Traglia M;Farmaki AE;Kacprowski T;Bjonnes A;van der Spek A;Wu Y;Giri AK;Yanek LR;Wang L;Hofer E;Rietveld CA;McLeod O;Cornelis MC;Pattaro C;Verweij N;Baumbach C;Abdellaoui A;Warren HR;Vuckovic D;Mei H;Bouchard C;Perry JRB;Cappellani S;Mirza SS;Benton MC;Broeckel U;Medland SE;Lind PA;Malerba G;Drong A;Yengo L;Bielak LF;Zhi D;van der Most PJ;Shriner D;Mägi R;Hemani G;Karaderi T;Wang Z;Liu T;Demuth I;Zhao JH;Meng W;Lataniotis L;van der Laan SW;Bradfield JP;Wood AR;Bonnefond A;Ahluwalia TS;Hall LM;Salvi E;Yazar S;Carstensen L;de Haan HG;Abney M;Afzal U;Allison MA;Amin N;Asselbergs FW;Bakker SJL;Barr RG;Baumeister SE;Benjamin DJ;Bergmann S;Boerwinkle E;Bottinger EP;Campbell A;Chakravarti A;Chan Y;Chanock SJ;Chen C;Chen YI;Collins FS;Connell J;Correa A;Cupples LA;Smith GD;Davies G;Dörr M;Ehret G;Ellis SB;Feenstra B;Feitosa MF;Ford I;Fox CS;Frayling TM;Friedrich N;Geller F;Scotland G;Gillham-Nasenya I;Gottesman O;Graff M;Grodstein F;Gu C;Haley C;Hammond CJ;Harris SE;Harris TB;Hastie ND;Heard-Costa NL;Heikkilä K;Hocking LJ;Homuth G;Hottenga JJ;Huang J;Huffman JE;Hysi PG;Ikram MA;Ingelsson E;Joensuu A;Johansson Å;Jousilahti P;Jukema JW;Kähönen M;Kamatani Y;Kanoni S;Kerr SM;Khan NM;Koellinger P;Koistinen HA;Kooner MK;Kubo M;Kuusisto J;Lahti J;Launer LJ;Lea RA;Lehne B;Lehtimäki T;Liewald DCM;Lind L;Loh M;Lokki ML;London SJ;Loomis SJ;Loukola A;Lu Y;Lumley T;Lundqvist A;Männistö S;Marques-Vidal P;Masciullo C;Matchan A;Mathias RA;Matsuda K;Meigs JB;Meisinger C;Meitinger T;Menni C;Mentch FD;Mihailov E;Milani L;Montasser ME;Montgomery GW;Morrison A;Myers RH;Nadukuru R;Navarro P;Nelis M;Nieminen MS;Nolte IM;O'Connor GT;Ogunniyi A;Padmanabhan S;Palmas WR;Pankow JS;Patarcic I;Pavani F;Peyser PA;Pietilainen K;Poulter N;Prokopenko I;Ralhan S;Redmond P;Rich SS;Rissanen H;Robino A;Rose LM;Rose R;Sala C;Salako B;Salomaa V;Sarin AP;Saxena R;Schmidt H;Scott LJ;Scott WR;Sennblad B;Seshadri S;Sever P;Shrestha S;Smith BH;Smith JA;Soranzo N;Sotoodehnia N;Southam L;Stanton AV;Stathopoulou MG;Strauch K;Strawbridge RJ;Suderman MJ;Tandon N;Tang ST;Taylor KD;Tayo BO;Töglhofer AM;Tomaszewski M;Tšernikova N;Tuomilehto J;Uitterlinden AG;Vaidya D;van Hylckama Vlieg A;van Setten J;Vasankari T;Vedantam S;Vlachopoulou E;Vozzi D;Vuoksimaa E;Waldenberger M;Ware EB;Wentworth-Shields W;Whitfield JB;Wild S;Willemsen G;Yajnik CS;Yao J;Zaza G;Zhu X;Project TBJ;Salem RM;Melbye M;Bisgaard H;Samani NJ;Cusi D;Mackey DA;Cooper RS;Froguel P;Pasterkamp G;Grant SFA;Hakonarson H;Ferrucci L;Scott RA;Morris AD;Palmer CNA;Dedoussis G;Deloukas P;Bertram L;Lindenberger U;Berndt SI;Lindgren CM;Timpson NJ;Tönjes A;Munroe PB;Sørensen TIA;Rotimi CN;Arnett DK;Oldehinkel AJ;Kardia SLR;Balkau B;Gambaro G;Morris AP;Eriksson JG;Wright MJ;Martin NG;Hunt SC;Starr JM;Deary IJ;Griffiths LR;Tiemeier H;Pirastu N;Kaprio J;Wareham NJ;Pérusse L;Wilson JG;Girotto G;Caulfield MJ;Raitakari O;Boomsma DI;Gieger C;van der Harst P;Hicks AA;Kraft P;Sinisalo J;Knekt P;Johannesson M;Magnusson PKE;Hamsten A;Schmidt R;Borecki IB;Vartiainen E;Becker DM;Bharadwaj D;Mohlke KL;Boehnke M;van Duijn CM;Sanghera DK;Teumer A;Zeggini E;Metspalu A;Gasparini P;Ulivi S;Ober C;Toniolo D;Rudan I;Porteous DJ;Ciullo M;Spector TD;Hayward C;Dupuis J;Loos RJF;Wright AF;Chandak GR;Vollenweider P;Shuldiner A;Ridker PM;Rotter JI;Sattar N;Gyllensten U;North KE;Pirastu M;Psaty BM;Weir DR;Laakso M;Gudnason V;Takahashi A;Chambers JC;Kooner JS;Strachan DP;Campbell H;Hirschhorn JN;Perola M;Polašek O;Wilson JF
通讯作者:
Wilson JF
影响因子:
5.3
作者:
Ostrer, Harry;Skorecki, Karl
通讯作者:
Skorecki, Karl