The population genetics of the Jewish people.
The population genetics of the Jewish people.
复制标题
犹太人的群体遗传学。
DOI：
10.1007/s00439-012-1235-6
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发表时间：
2013-02
期刊：
影响因子：
5.3
通讯作者：
Skorecki, Karl
中科院分区：
文献类型：
--
作者：
Ostrer, Harry;Skorecki, Karl
三千年来，犹太信仰的信徒居住在许多地理位置。在过去的二十年中，多个研究小组独立进行的逐步更详细的群体遗传分析揭示了来自全球散居社区的当代犹太人后裔的群体遗传结构模式。这种模式与共同的近东血统的主要但可变的组成部分一致，以及来自相应寄主散居人群的不同程度的混合和渗入。通过将单等位标记的分析与最近对简单串联重复、拷贝数变异和高密度单核苷酸多态性的全基因组变异分析相结合，已经可以确定性别特异性迁移和基因渗入对图谱创始人事件的相对贡献，并提出与西部和东部侨民迁徙相对应的人口历史，以及随后的微进化事件。这些模式与许多人的推论一致，但并非所有历史学家使用更传统的工具，如考古学、档案记录、语言学、宗教叙事、礼拜仪式和实践的比较分析。重要的是，犹太人的群体遗传结构有助于解释观察到的健康和疾病相关突变和表型的模式，这些模式和表型继续得到仔细研究和编目，并代表了人类医学遗传学研究的重要资源。当前的综述试图提供历史和人类健康背景下最新发展的简洁更新。本文的在线版本 (doi:10.1007/s00439-012-1235-6) 包含补充材料，可供授权用户使用。
Adherents to the Jewish faith have resided in numerous geographic locations over the course of three millennia. Progressively more detailed population genetic analysis carried out independently by multiple research groups over the past two decades has revealed a pattern for the population genetic architecture of contemporary Jews descendant from globally dispersed Diaspora communities. This pattern is consistent with a major, but variable component of shared Near East ancestry, together with variable degrees of admixture and introgression from the corresponding host Diaspora populations. By combining analysis of monoallelic markers with recent genome-wide variation analysis of simple tandem repeats, copy number variations, and single-nucleotide polymorphisms at high density, it has been possible to determine the relative contribution of sex-specific migration and introgression to map founder events and to suggest demographic histories corresponding to western and eastern Diaspora migrations, as well as subsequent microevolutionary events. These patterns have been congruous with the inferences of many, but not of all historians using more traditional tools such as archeology, archival records, linguistics, comparative analysis of religious narrative, liturgy and practices. Importantly, the population genetic architecture of Jews helps to explain the observed patterns of health and disease-relevant mutations and phenotypes which continue to be carefully studied and catalogued, and represent an important resource for human medical genetics research. The current review attempts to provide a succinct update of the more recent developments in a historical and human health context. The online version of this article (doi:10.1007/s00439-012-1235-6) contains supplementary material, which is available to authorized users.
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影响因子：
2.8
作者：
BONNETAMIR, B;ASHBEL, S;BARSHANI, S
通讯作者：
BARSHANI, S
影响因子：
5.3
作者：
BONNETAMIR, B;ASHBEL, S;MODAI, J
通讯作者：
MODAI, J
影响因子：
2.8
作者：
BONNETAMIR, B;ASHBEL, S;BARSHANI, S
通讯作者：
BARSHANI, S
DOI：
10.1073/pnas.0914618107
发表时间：
2010-05-11
影响因子：
11.1
作者：
Bryc, Katarzyna;Velez, Christopher;Ostrer, Harry
通讯作者：
Ostrer, Harry
影响因子：
9.8
作者：
Atzmon, Gil;Hao, Li;Ostrer, Harry
通讯作者：
Ostrer, Harry