Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications.

Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications.
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DOI:
10.1155/2015/143720
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发表时间:
2015
影响因子:
--
通讯作者:
Lin P
Lin P
中科院分区:
生物学3区
文献类型:
--
作者:
Luo YH;Chang LW;Lin P

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纳米材料,包括金属基纳米颗粒,被用于各种生物和医学应用。然而,金属会影响包括人类在内的许多动物的免疫功能。不同的物理和化学性质诱导不同的细胞反应,如细胞摄取和细胞内生物分布,导致不同的免疫反应。本综述的目的是总结和讨论金属基纳米颗粒在各种免疫系统模型中引发的先天和适应性免疫反应。
Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.
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