Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer.
Effects of NFKB1 and NFKBIA gene polymorphisms on susceptibility to environmental factors and the clinicopathologic development of oral cancer.
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DOI：
10.1371/journal.pone.0035078
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Chien MH
中科院分区：
文献类型：
--
作者：
Lin CW;Hsieh YS;Hsin CH;Su CW;Lin CH;Wei LH;Yang SF;Chien MH
口腔癌是台湾男性第四常见的癌症，与环境致癌物质有关。核因子-kappaB(NF-κB)信号通路激活中的遗传易感性与口腔鳞状细胞癌的发生有关的可能性有待研究。本研究探讨了编码NF-κB1和IkappaBalpha(IκBα)的NFKB1和NFKBIA启动子区域的多态性与口腔鳞癌的易感性和肿瘤的临床病理特征之间的关系。采用实时定量聚合酶链式反应(Real-time PCR)技术，对462例口腔癌患者和520例非肿瘤对照进行了NFKB1和NFKBIA基因多态性分析。结果发现，口腔鳞癌患者中NFKB1ATG1ATG1ATGG2、−94ATGG2ATGG2、−94ATGG1ATGG2和−94ATGG1ATGG2ATGG2ATGG2/ATGG2等位基因携带者中，−826T(CT+TT)和−881G(AG+GG)等位基因携带者的比例明显高于非癌症患者。此外，我们发现NFKB1或NFKBIA基因多态似乎与槟榔和烟草消费相关的口腔癌易感性有关。最后，与CC纯合子相比，NFKBIA基因至少有一个−519T等位基因的口腔癌患者发生远处转移的风险更高(P<；0.05)。结果提示，NFKB1ATTG2、−−826T和−881G等位基因与口腔癌的发生有关。NFKB1或NFKBIA基因多态和环境致癌物的组合似乎与口腔癌风险增加有关。更重要的是，NFKBIA−519基因多态性可能是台湾人口腔鳞癌远处转移的预测因素。
Oral cancer, which is the fourth most common cancer in Taiwanese men, is associated with environmental carcinogens. The possibility that genetic predisposition in nuclear factor-kappa B (NF-κB)-signaling pathways activation is linked to the development of oral squamous cell carcinoma (OSCC) requires investigation. The current study examines associations between polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IkappaBalpha (IκBα) with both the susceptibility to develop OSCC and the clinicopathological characteristics of the tumors. Genetic polymorphisms of NFKB1 and NFKBIA were analyzed by a real-time polymerase chain reaction (real-time PCR) for 462 patients with oral cancer and 520 non-cancer controls. We found that NFKB1 −94 ATGG1/ATGG2, −94 ATGG2/ATGG2, and the combination of −94 ATGG1/ATGG2 and ATGG2/ATGG2 genotypes NFKBIA −826 T (CT+TT) and −881 G (AG+GG) allelic carriages, were more prevalent in OSCC patients than in non-cancer participants. Moreover, we found that NFKB1 or NFKBIA gene polymorphisms seem to be related to susceptibility to develop oral cancer linked to betel nut and tobacco consumption. Finally, patients with oral cancer who had at least one −519 T allele of the NFKBIA gene were at higher risk for developing distant metastasis (P<.05), compared with those patients CC homozygotes. Our results suggest that NFKB1 −94 ATTG2, NFKBIA −826 T, and −881 G alleles are associated with oral carcinogenesis. The combination of NFKB1 or NFKBIA gene polymorphisms and environmental carcinogens appears related to an increased risk of oral cancer. More importantly, the genetic polymorphism of NFKBIA −519 might be a predictive factor for the distal metastasis of OSCC in Taiwanese.
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影响因子：
3.3
作者：
Lin, Pin-Yi;Yu, Chuan-Hang;Chiang, Chun-Pin
通讯作者：
Chiang, Chun-Pin
DOI：
10.1621/nrs.07003
发表时间：
2009
期刊：
Nuclear receptor signaling
影响因子：
--
作者：
Jetten AM
通讯作者：
Jetten AM
影响因子：
9.7
作者：
Curran, JE;Weinstein, SR;Griffiths, LR
通讯作者：
Griffiths, LR
影响因子：
6.4
作者：
Lin, SC;Lu, SY;Chang, KW
通讯作者：
Chang, KW
影响因子：
8
作者：
Dong, QG;Sclabas, GM;Chiao, PJ
通讯作者：
Chiao, PJ