Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
Maternal iron deficiency perturbs embryonic cardiovascular development in mice.
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DOI：
10.1038/s41467-021-23660-5
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发表时间：
2021-06-08
影响因子：
16.6
通讯作者：
Sparrow DB
中科院分区：
文献类型：
--
作者：
Kalisch-Smith JI;Ved N;Szumska D;Munro J;Troup M;Harris SE;Rodriguez-Caro H;Jacquemot A;Miller JJ;Stuart EM;Wolna M;Hardman E;Prin F;Lana-Elola E;Aoidi R;Fisher EMC;Tybulewicz VLJ;Mohun TJ;Lakhal-Littleton S;De Val S;Giannoulatou E;Sparrow DB
先天性心脏病(CHD)是人类最常见的一类出生缺陷，发病率为0.9%。然而，三分之二的病例原因不明，其中许多被认为是由宫内暴露于环境致畸物质引起的。在这里，我们确定了一种潜在的致畸因素：母体缺铁(ID)。我们发现，小鼠的母体ID会导致子代严重的心血管缺陷。这些缺陷可能是由于ID胚胎中维甲酸信号的增加引起的。这些缺陷可以通过在怀孕早期服用铁剂来预防。也有人提出，致畸剂暴露可能通过基因-环境相互作用增强遗传易感性对CHD的影响。在这里，我们表明，母亲ID增加了唐氏综合症小鼠模型的心脏和颅面部缺陷的严重程度。重要的是要了解在老鼠身上看到的母体ID的影响是否对女性有临床意义。从小鼠实验中，作者发现母亲缺铁与心血管缺陷和后代维甲酸信号增加有关，怀孕早期补铁可以预防大多数缺陷。
Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene–environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women. From mouse experiments, the authors link iron deficiency in mothers with cardiovascular defects and increased retinoic acid signalling in their offspring, and giving iron early in pregnancy can prevent most defects.
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DOI：
10.1002/ar.24020
发表时间：
2019-01-01
影响因子：
2
作者：
Anderson, Robert H.;Spicer, Diane E.;Lamers, Wouter H.
通讯作者：
Lamers, Wouter H.
影响因子：
3.5
作者：
Chapman, Gavin;Moreau, Julie L. M.;Dunwoodie, Sally L.
通讯作者：
Dunwoodie, Sally L.
影响因子：
4.6
作者：
Chen, Heidi I.;Sharma, Bikram;Red-Horse, Kristy
通讯作者：
Red-Horse, Kristy
影响因子：
2
作者：
Bellini, Carlo;Donarini, Gloria;Hennekam, Raoul C.
通讯作者：
Hennekam, Raoul C.
影响因子：
5.3
作者：
ARCECI, RJ;KING, AAJ;WILSON, DB
通讯作者：
WILSON, DB