Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.
Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity.
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DOI：
10.1016/j.biopsych.2009.05.012
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发表时间：
2009-10-01
影响因子：
10.6
通讯作者：
Carpenter, Linda L.
中科院分区：
文献类型：
--
作者：
Tyrka, Audrey R.;Price, Lawrence H.;Gelernter, Joel;Schepker, Caroline;Anderson, George M.;Carpenter, Linda L.
促肾上腺皮质激素释放激素受体（CRHR1）基因的变异已被证明与早期生活压力相互作用，可以预测成年后的抑郁症。本研究旨在确定CRHR1多态性是否与儿童虐待相互作用，以预测HPA轴的反应性，这与抑郁症和早期生活压力有关。129名非西班牙裔白人成年人完成了儿童创伤问卷、地塞米松/促肾上腺皮质激素释放激素测试，并提供了两种CRHR1多态性基因分型的血液样本。在Dex/CRH测试中，rs110402和rs242924 （D ' =0.98）在预测皮质醇反应方面与虐待有显著的交互作用（p< 0.05）。对于遭受虐待的受试者，每个SNP的GG基因型与皮质醇对测试的反应升高有关。CRHR1的变异调节儿童虐待对Dex/CRH测试皮质醇反应的影响。HPA轴过度激活可能是情绪和焦虑障碍发生过程中风险基因与应激相互作用的一种机制。
Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early-life stress to predict adult depression. This study was conducted to determine whether CRHR1 polymorphisms interact with childhood maltreatment to predict HPA axis reactivity, which has been linked to both depression and early-life stress. One-hundred twenty-nine White non-Hispanic adults completed the Childhood Trauma Questionaire, the dexamethasone/corticotropin-releasing hormone test, and provided blood samples for genotyping of two CRHR1 polymorphisms. Both rs110402 and rs242924 (which were in tight linkage disequilibrium, D’=0.98) showed a significant interaction with maltreatment in the prediction of cortisol response to the Dex/CRH test (p<.05). For subjects with maltreatment, the GG genotype of each SNP was associated with elevated cortisol responses to the test. Variation in the CRHR1 moderates the effect of childhood maltreatment on cortisol responses to the Dex/CRH test. Excessive HPA axis activation could represent a mechanism of interactions of risk genes with stress in the development of mood and anxiety disorders.
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影响因子：
10.6
作者：
Carpenter, Linda L.;Carvalho, John P.;Price, Lawrence H.
通讯作者：
Price, Lawrence H.
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
3.7
作者：
Schuele, Cornelius;Zill, Peter;Bondy, Brigitta
通讯作者：
Bondy, Brigitta
DOI：
10.1136/mp.52.5.295
发表时间：
1999-10-01
期刊：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY
影响因子：
--
作者：
Shi, MM;Myrand, SP;de la Iglesia, FA
通讯作者：
de la Iglesia, FA
影响因子：
11
作者：
Hiroi, N;Wong, ML;Bornstein, SR
通讯作者：
Bornstein, SR