Transcriptional profiling of macrophages infected with Fonsecaea monophora
Transcriptional profiling of macrophages infected with Fonsecaea monophora
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感染 Fonsecaea monophora 的巨噬细胞的转录谱
DOI：
10.1111/myc.12894
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发表时间：
2019-04
期刊：
影响因子：
4.9
通讯作者：
jinglin qin
中科院分区：
文献类型：
--
作者：
junmin zhang;minglan shi;jinglin qin
单色真菌是一种能够通过创伤性损伤引起成色菌病的真菌。然而，关于单孢单胞菌的发病机制和与宿主的早期相互作用知之甚少。本研究旨在探讨巨噬细胞对单孢镰刀菌的潜在作用机制，特别是黑色素在其致病过程中的作用。我们基于Illumina系统进行了RNA测序。结果表明，根据黑色素含量的不同，不同菌株在巨噬细胞中诱导的转录谱不同。功能分析表明，差异表达基因的生物学功能与免疫应答密切相关，黑色素可能通过调控巨噬细胞的MAPK信号通路影响相互作用。我们的研究结果为分生单孢单胞菌感染的发病机制提供了见解。
Fonsecaea monophora is a member of dematiaceous fungi capable of causing chromoblastomycosis through traumatic injury. However, little is known about the pathogenesis and early interactions between F. monophora and host. The aim of this study was to explore the potential mechanism of macrophages against F. monophora, especially the role of melanin during the pathogenic process. We carried out RNA sequencing based on the Illumina system. It showed that according to melanin contents, different strains of F. monophora induced different transcriptional profilings in macrophages. Functional analyses suggested the biological functions of differentially expressed genes were closely related to immune response, and the melanin might affect the interactions by regulating the MAPK signalling pathway of macrophages. Our results provide insights into the pathogenesis of infection by F. monophora conidia.
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影响因子：
46.9
作者：
Trapnell C;Williams BA;Pertea G;Mortazavi A;Kwan G;van Baren MJ;Salzberg SL;Wold BJ;Pachter L
通讯作者：
Pachter L
对真菌病原体的先天防御。
影响因子：
5.4
作者：
Drummond RA;Gaffen SL;Hise AG;Brown GD
通讯作者：
Brown GD
影响因子：
5.5
作者：
Bocca, AL;Brito, PMS;Tosta, CE
通讯作者：
Tosta, CE
影响因子：
5.5
作者：
Junmin Zhang;Li Wang;L. Xi;Huaiqiu Huang;Yongxuan Hu;Xi-qing Li;Xiao Huang;Sha Lu;Jiufeng Sun
通讯作者：
Junmin Zhang;Li Wang;L. Xi;Huaiqiu Huang;Yongxuan Hu;Xi-qing Li;Xiao Huang;Sha Lu;Jiufeng Sun
影响因子：
1.1
作者：
H. Takei;J. Goodman;S. Powell
通讯作者：
H. Takei;J. Goodman;S. Powell