Severe Asthma with Fungal Sensitisation (SAFS)
Severe Asthma with Fungal Sensitisation (SAFS)
复制标题
真菌致敏的严重哮喘 (SAFS)
DOI：
--
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Niven
中科院分区：
文献类型：
--
作者：
C. Prys;R. Niven
哮喘是一种越来越常见的疾病。那些患有最严重疾病的患者消耗了不成比例的高比例医疗预算。对多种真菌（包括曲霉属）致敏。通常存在于特应性个体中。真菌致敏与哮喘药物使用增加、测量的哮喘严重程度、哮喘入院、哮喘重症监护入院、呼吸骤停和哮喘死亡相关。已经提出了真菌诱导过敏反应的能力的许多机制。这些包括真菌释放的广谱过敏分子，特别是那些具有固有蛋白水解活性的分子。挥发性有机化合物也有牵连，但这方面的证据不太有力。过敏性支气管肺曲霉病（ABPA）是典型的过敏性真菌病，其中烟曲霉在致敏个体的气道中定殖，并且与烟曲霉特异性IgE和IgG的形成相关。真菌敏感性重度哮喘（SAFS）描述了一组具有难治性哮喘症状，对一种或多种常见真菌敏感，但缺乏ABPA诊断标准（如曲霉特异性IgG）的哮喘患者。这种经验分类的重要性在于对抗真菌治疗的反应。FAST试验表明，与安慰剂相比，伊曲康唑治疗后，这些患者的生活质量、鼻炎评分和血清IgE降低均有临床和统计学显著改善。
Asthma is an increasingly common disease. Those patients with the most severe disease consume a disproportionately high percentage of the healthcare budget. Sensitisation to a number of fungi including Aspergillus spp. is commonly found in atopic individuals. Sensitisation to fungi is associated with increased asthma medication usage, measured asthma severity, asthma admissions, intensive care admissions for asthma, respiratory arrest and asthma deaths. A number of mechanisms have been proposed for the ability of fungi to induce an allergic response. These include the wide spectrum of allergenic molecules released by fungi, especially those with inherent proteolytic activity. Volatile organic compounds have also been implicated but the evidence for this is less strong. Allergic bronchopulmonary aspergillosis (ABPA) is the archetypal allergic fungal disease whereby Aspergillus fumigatus colonises the airway in a sensitised individual, and is associated with the formation of Aspergillus-specific IgE and IgG. Severe asthma with fungal sensitivity (SAFS) describes a group of asthma patients with refractory asthma symptoms, sensitisation to one or more common fungi, but lacking the diagnostic criteria for ABPA (such as Aspergillus-specific IgG). The importance of this empirical categorization lies in the response to anti-fungal therapy. The FAST trial showed that such patients had both clinically and statistically significant improvements in quality of life, rhinitis scores, and reductions in serum IgE in response to itraconazole when compared to placebo.
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室外真菌孢子浓度对每日哮喘严重程度的影响。
影响因子：
10.4
作者：
通讯作者：
--
影响因子：
14.2
作者：
TARGONSKI, PV;PERSKY, VW;RAMEKRISHNAN, V
通讯作者：
RAMEKRISHNAN, V
轻度、中度和致命/近乎致命哮喘中的β2-肾上腺素受体单倍型。
DOI：
10.1164/ajrccm.158.3.9801035
发表时间：
1998
期刊：
American journal of respiratory and critical care medicine.
影响因子：
--
作者：
Weir,TD;Mallek,N;Sandford,AJ;Bai,TR;Awadh,N;Fitzgerald,JM;Cockcroft,D;James,A;Liggett,SB;Pare,PD
通讯作者：
Pare,PD
影响因子：
158.5
作者：
Stevens, DA;Schwartz, HJ;Reuman, P
通讯作者：
Reuman, P
影响因子：
14.2
作者：
Ward, GW;Woodfolk, JA;Platts-Mills, TAE
通讯作者：
Platts-Mills, TAE