The Neural Representation of a Repeated Standard Stimulus in Dyslexia.
The Neural Representation of a Repeated Standard Stimulus in Dyslexia.
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DOI：
10.3389/fnhum.2022.823627
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发表时间：
2022
影响因子：
2.9
通讯作者：
Gabrieli, John D. E.
中科院分区：
文献类型：
--
作者：
Beach, Sara D.;Ozernov-Palchik, Ola;May, Sidney C.;Centanni, Tracy M.;Perrachione, Tyler K.;Pantazis, Dimitrios;Gabrieli, John D. E.
关键词：
重复刺激的神经表征是大脑中测量异常刺激的标准，从而产生众所周知的失配反应。有人认为，患有阅读障碍的人对最近重复的刺激（例如奇怪范式中的标准序列）的内隐记忆较差。在这里，我们研究了标准的神经表征如何在重复中出现，询问阅读障碍患者是否对重复的敏感性较低和/或在连续重复中“标准性”的累积较少。我们记录了患有或不患有阅读障碍的成年人在流动奇怪的设计中被动暴露于语音音节的脑磁图（MEG）。我们对 MEG 传感器数据进行时间分辨多变量解码，以识别标准试验与异常试验的神经特征，而与刺激差异无关。这种“多变量不匹配”同样强大，并且在两组中具有相似的时间进程。在两组中，只需两次重复产生的标准就与异常者不同，表明阅读障碍患者对重复的正常敏感性。然而，只有在对照组中，随着重复，标准与异常者的差异越来越大。这些结果表明，在阅读障碍中，引起神经适应和失配反应的许多机制是完整的，但可能的例外是推定的预测机制，该机制连续地将最近的感觉信息整合到前馈处理中。
The neural representation of a repeated stimulus is the standard against which a deviant stimulus is measured in the brain, giving rise to the well-known mismatch response. It has been suggested that individuals with dyslexia have poor implicit memory for recently repeated stimuli, such as the train of standards in an oddball paradigm. Here, we examined how the neural representation of a standard emerges over repetitions, asking whether there is less sensitivity to repetition and/or less accrual of “standardness” over successive repetitions in dyslexia. We recorded magnetoencephalography (MEG) as adults with and without dyslexia were passively exposed to speech syllables in a roving-oddball design. We performed time-resolved multivariate decoding of the MEG sensor data to identify the neural signature of standard vs. deviant trials, independent of stimulus differences. This “multivariate mismatch” was equally robust and had a similar time course in the two groups. In both groups, standards generated by as few as two repetitions were distinct from deviants, indicating normal sensitivity to repetition in dyslexia. However, only in the control group did standards become increasingly different from deviants with repetition. These results suggest that many of the mechanisms that give rise to neural adaptation as well as mismatch responses are intact in dyslexia, with the possible exception of a putatively predictive mechanism that successively integrates recent sensory information into feedforward processing.
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影响因子：
2.5
作者：
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通讯作者：
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作者：
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通讯作者：
Sprenger-CharolleS, L.
DOI：
10.1016/j.cortex.2015.11.024
发表时间：
2016-07
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Auksztulewicz R;Friston K
通讯作者：
Friston K