Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats
Nerve Growth Factor Differentially Affects Spatial and Recognition Memory in Aged Rats
复制标题
神经生长因子对老年大鼠的空间记忆和识别记忆有不同影响
作者：
Grazyna Niewiadomska;M. Baksalerska;A. Gąsiorowska;A. Mietelska
在大鼠中，物体辨别依赖于胆碱能系统的完整性，因此可以预期神经生长因子（NGF）可以改善老年人的行为。年龄和胆碱能改善的相互作用进行了评估，在年轻和老年大鼠的行为。通过将NGF注入动物的侧脑室，并在两个行为任务中对它们进行测试：对象定位和对象识别任务。空间和识别记忆进行了评估，在一个开放的领域，包含五个不同的对象。将大鼠提交至六个连续的阶段。两个年龄组在第1-4阶段的探索性应答习惯相当。计算辨别指数（DI），以评估第5阶段对空间变化的反应和第6阶段对物体变化的反应。对照组青年和老年大鼠能够区分熟悉和新的对象，但DI在老年大鼠较低。用NGF治疗引起两个年龄组的物体辨别力下降。在空间位移试验中得到了不同的结果。NGF能够改善老年大鼠的空间记忆，但对年轻对照组没有影响。这些数据赋予神经生长因子的潜在作用，在改善空间，但不是情节记忆在老年大鼠。
In rats, object discrimination depends on the integrity of the cholinergic system, thus it could be expected that nerve growth factor (NGF) can improve the behavior in aged subjects. The interactive effect of age and cholinergic improvement was assessed behaviorally in young and aged rats. Animals were injected by infusion of NGF into the lateral ventricles and they were tested in two behavioral tasks: an object-location and an object-recognition task. Spatial and recognition memory were assessed in an open field containing five different objects. Rats were submitted to six consecutive sessions. Both age-groups showed comparable habituation of exploratory response in Session 1–4. Discrimination index (DI) was calculated to assess responses to spatial change in Session 5 and object change in Session 6. Control young and aged rats were able to discriminate between familiar and novel object, however DI was lower in aged rats. Treatment with NGF induced decline of object discrimination in both age-groups. Different results were obtained in spatial displacement test. NGF was able to improve spatial memory in aged rats, but had no effect in young controls. These data confer on NGF potential role in improving spatial but not episodic memory in aged rats.
顶叶皮层和海马体在表示空间信息中的作用。
DOI：
10.1093/cercor/1.5.367
发表时间：
1991
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Kesner,RP;Farnsworth,G;Kametani,H
通讯作者：
Kametani,H
影响因子：
2.7
作者：
M. Voytko
通讯作者：
M. Voytko
空间认知图：顶叶皮层和海马结构的不同作用。
影响因子：
1.9
作者：
DiMattia,BD;Kesner,RP
通讯作者：
Kesner,RP