Risk Factors for Progression of Age-Related Macular Degeneration: Population-Based Amish Eye Study.
Risk Factors for Progression of Age-Related Macular Degeneration: Population-Based Amish Eye Study.
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DOI：
10.3390/jcm11175110
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发表时间：
2022-08-30
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
目的：在一项针对老年阿米什人的人群研究中，评估基于光学相干断层扫描 (OCT) 的进展为晚期年龄相关性黄斑变性 (AMD) 的危险因素。方法：这项多中心、前瞻性、纵向观察性研究纳入了完成 2 年随访的 666 名连续受试者的 1332 只眼睛。影像学特征与晚期 AMD 发展的 2 年发病率相关。成像特征的优势比是通过逻辑回归估计的。检查基线 OCT 图像是否存在中央 3 mm 环中玻璃膜疣体积≥0.03 mm3、视网膜内高反射灶 (IHRF)、低反射性玻璃膜疣核心 (hDC)、视网膜下玻璃膜疣沉积物 (SDD) 和玻璃膜疣色素上皮脱离 (PED)。还评估了中心凹下脉络膜厚度、玻璃疣面积以及以中心凹为中心的 3 和 5 毫米圆圈内的玻璃疣体积。结果：1332 只眼睛中有 21 只 (1.5%) 在 2 年后进展为晚期 AMD。研究对象的平均年龄为 65 ± 10.17 (±SD) 岁，其中 410 名对象为女性。单变量逻辑回归显示，3 mm 和 5 mm 环中的玻璃疣面积和体积、中心凹下脉络膜厚度、3 mm 环中的玻璃疣体积≥ 0.03 mm3、SDD、IHRF 和 hDC 均与晚期 AMD 发生风险增加相关。多变量回归模型确定 3 mm 环中的玻璃膜疣体积（OR：2.59，p = 0.049）和 IHRF 的存在（OR：57.06，p < 0.001）仍然是进展为晚期 AMD 的独立且重要的危险因素。结论：这项基于人群的研究证实了之前基于临床的研究结果，即高中央玻璃膜疣体积和 IHRF 与进展为晚期 AMD 的风险增加相关。这些发现对于临床实践中对患者进行风险分层或确定早期干预临床试验的受试者可能有价值。
Objective: To evaluate the optical coherence tomography (OCT)-based risk factors for progression to late age-related macular degeneration (AMD) in a population-based study of elderly Amish. Methods: A total of 1332 eyes of 666 consecutive subjects who completed a 2-year follow-up visit were included in this multicenter, prospective, longitudinal, observational study. Imaging features were correlated with 2-year incidence of late AMD development. Odds ratios for imaging features were estimated from logistic regression. Baseline OCT images were reviewed for the presence of drusen volume ≥0.03 mm3 in the central 3 mm ring, intraretinal hyperreflective foci (IHRF), hyporeflective drusen cores (hDC), subretinal drusenoid deposits (SDD), and drusenoid pigment epithelium detachment (PED). Subfoveal choroidal thickness, drusen area, and drusen volume within 3 and 5 mm circles centered on the fovea were also assessed. Results: Twenty-one (1.5%) of 1332 eyes progressed to late AMD by 2 years. The mean age of the study subjects was 65 ± 10.17 (±SD) years and 410 subjects were female. Univariate logistic regression showed that drusen area and volume in both 3 mm and 5 mm circles, subfoveal choroidal thickness, drusen volume ≥ 0.03 mm3 in the 3 mm ring, SDD, IHRF, and hDC were all associated with an increased risk for development of late AMD. The multivariate regression model identified that drusen volume in the 3 mm ring (OR: 2.59, p = 0.049) and presence of IHRF (OR: 57.06, p < 0.001) remained as independent and significant risk factors for progression to late AMD. Conclusions: This population-based study confirms previous findings from clinic-based studies that high central drusen volume and IHRF are associated with an increased risk of progression to late AMD. These findings may be of value in risk-stratifying patients in clinical practice or identifying subjects for early intervention clinical trials.
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影响因子：
13.7
作者：
Finger, Robert P.;Chong, Elaine;Guymer, Robyn H.
通讯作者：
Guymer, Robyn H.
影响因子：
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作者：
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影响因子：
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作者：
Lindner, Moritz;Bezatis, Athanasios;Fleckenstein, Monika
通讯作者：
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DOI：
10.1097/iae.0000000000002990
发表时间：
2021-04-01
影响因子：
3.3
作者：
Corvi, Federico;Tiosano, Liran;Sadda, Srinivas R.
通讯作者：
Sadda, Srinivas R.
影响因子：
4.4
作者：
Nittala, Muneeswar Gupta;Ruiz-Garcia, Humberto;Sadda, SriniVas R.
通讯作者：
Sadda, SriniVas R.