Genetic Ancestry for Sleep Research: Leveraging Health Inequalities to Identify Causal Genetic Variants.
Genetic Ancestry for Sleep Research: Leveraging Health Inequalities to Identify Causal Genetic Variants.
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DOI：
10.1016/j.chest.2018.03.024
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发表时间：
2018-06
期刊：
影响因子：
9.6
通讯作者：
Patel SR
中科院分区：
文献类型：
--
作者：
Prasad B;Saxena R;Goel N;Patel SR
最近的证据强调了睡眠行为和睡眠障碍方面的健康不平等，这对包括非洲裔美国人和西班牙裔美国人在内的特定人群产生了不利影响。与种族有关的睡眠健康不平等归因于多层次和相互关联的健康决定因素的差异，如社会人口因素、健康行为和生物学。非洲裔美国人和西班牙裔美国人是混血儿，他们的基因遗传结合了两个或两个以上来自不同大陆的祖先。混合人口中的种族不平等可以通过使用遗传祖先的测量方法解析为相关的中介因素组（环境与遗传），遗传祖先是指来自每个主要祖先大陆人口的个体基因构成的比例。这篇综述描述了非裔美国人和西班牙裔美国人的睡眠健康不平等，并考虑了祖先研究的潜在效用，利用这些差异来深入了解这些表型的遗传基础。在未来的混合人群研究中纳入遗传方法将有助于更好地了解与种族相关的睡眠健康不平等的潜在生物学基础。
Recent evidence has highlighted the health inequalities in sleep behaviors and sleep disorders that adversely impact outcomes in select populations, including African Americans and Hispanic Americans. Race-related sleep health inequalities are ascribed to differences in multilevel and interlinked health determinants, such as sociodemographic factors, health behaviors and biology. African Americans and Hispanic Americans are admixed populations whose genetic inheritance combines two or more ancestral populations originating from different continents. Racial inequalities in admixed populations can be parsed into relevant groups of mediating factors (environmental versus genetic) with the use of measures of genetic ancestry, the proportion of an individual’s genetic make-up that comes from each of the major ancestral continental populations. This review describes sleep health inequalities in African Americans and Hispanic Americans and considers the potential utility of ancestry studies to exploit these differences to gain insight into the genetic underpinnings of these phenotypes. The inclusion of genetic approaches in future studies of admixed populations will allow greater understanding of the potential biological basis of race-related sleep health inequalities.
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影响因子：
--
作者：
Alkhazna, Ammar;Bhat, Abid;Bohnam, Aaron J
通讯作者：
Bohnam, Aaron J
影响因子：
9.6
作者：
Ancoli-Israel, S;Stepnowsky, C;Johnson, S
通讯作者：
Johnson, S
影响因子：
2.9
作者：
Allen, Kelli D.;Renner, Jordan B.;Jordan, Joanne M.
通讯作者：
Jordan, Joanne M.
影响因子：
3.5
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Ciarleglio CM;Ryckman KK;Servick SV;Hida A;Robbins S;Wells N;Hicks J;Larson SA;Wiedermann JP;Carver K;Hamilton N;Kidd KK;Kidd JR;Smith JR;Friedlaender J;McMahon DG;Williams SM;Summar ML;Johnson CH
通讯作者：
Johnson CH
DOI：
10.1534/g3.116.028779
发表时间：
2016-06-01
期刊：
G3 (Bethesda, Md.)
影响因子：
--
作者：
Browning SR;Grinde K;Plantinga A;Gogarten SM;Stilp AM;Kaplan RC;Avilés-Santa ML;Browning BL;Laurie CC
通讯作者：
Laurie CC