International survey of apolipoproteins A1 and B measurements (1983-1984).
International survey of apolipoproteins A1 and B measurements (1983-1984).
复制标题
国际载脂蛋白 A1 和 B 测量调查（1983-1984 年）。
作者：
G. Cooper;S. J. Smith;D. Wiebe;M. Kuchmak;W. H. Hannon
我们在这里报告载脂蛋白（apo）A1和B测量的全球调查结果。为调查开发了人血清冻干池，以检测其作为候选参比物质的适用性。来自18个国家的75个实验室应邀参加。他们使用几种方法评价了拟定参比物质中载脂蛋白A1和B的质量浓度。然后描述实验室之间和分析方法之间的偏倚。55个实验室在截止日期前报告了通过一种方法测量至少一种载脂蛋白的结果。合作者之间载脂蛋白A1和B的变异构成了研究中最大的误差来源（载脂蛋白A1占总变异的68%，载脂蛋白B占73%）。对于apo A1，方法平均值之间的变异不显著，但对于apo B，其占总变异的20%。发现小瓶或小瓶内重复测量导致的差异占总变异性的6%或更少。本研究的实验室内、小瓶内和重复测定CV值均小于5%。这些结果表明，未来的标准化工作可以取得成功。
We report here results of a worldwide survey of apolipoprotein (apo) A1 and B measurements. A lyophilized pool of human serum was developed for the survey to test its suitability as a candidate Reference Material. Seventy-five laboratories from 18 countries responded to invitations to participate. Using several methods, they evaluated the mass concentration of apo A1 and B in the proposed Reference Material. The bias between laboratories and between analytical methods was then characterized. Fifty-five laboratories reported results before the deadline on measurement of at least one apolipoprotein by one method. Variation in apo A1 and B among collaborators constituted the largest source of error in the study (68% of the total variation for apo A1, 73% for apo B). Variation among method means was not significant for apo A1, but for apo B it constituted 20% of the total variation. Differences due to vials or in replicate measurements within vials were found to constitute 6% or less of the total variability. Within-laboratory, among-vial, and among-replicate CV values were less than 5% for the study. These results suggest that future standardization efforts can be successful.
影响因子：
56.9
作者：
BROWN, MS;KOVANEN, PT;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL
脂质研究诊所冠状动脉一级预防试验结果。
DOI：
10.1001/jama.1984.03340270029025
发表时间：
1984
期刊：
JAMA
影响因子：
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通讯作者：
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