Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation.
Multimodal structural neuroimaging markers of risk and recovery from posttrauma anhedonia: A prospective investigation.
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DOI：
10.1002/da.23104
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发表时间：
2021-01
影响因子：
7.4
通讯作者：
Fani N
中科院分区：
文献类型：
--
作者：
Harnett NG;Stevens JS;van Rooij SJH;Ely TD;Michopoulos V;Hudak L;Jovanovic T;Rothbaum BO;Ressler KJ;Fani N
创伤后应激障碍（PTSD）的快感缺乏症状反映了奖励处理的缺陷，具有显著的功能后果。尽管最近的证据表明，额边缘电路完整性的破坏与PTSD的发展有关，包括创伤后快感缺乏症（创伤后快感缺乏症；PTA），但对于长期PTA的潜在结构生物标志物以及与PTA随时间恢复相关的额边缘通路的结构变化知之甚少。我们调查了75名最近遭受创伤的个体的白质微观结构、灰质体积和PTA之间的关系，其中一部分参与者（n = 35）在创伤暴露12个月后完成了随访评估。使用确定性神经束造影和基于体素的形态测量来评估与PTA变化相关的白质和灰质结构的变化。创伤前后钩侧束分数各向异性（FA）的降低预示着创伤后12个月PTA的增加。此外，创伤后1至12个月间，穹窿FA的增加与PTA的降低有关。随着时间的推移，腹内侧PFC和楔前叶灰质体积的增加也与PTA降低有关。钩状束的微观结构，杏仁核-前额叶白质连接，可能是后发PTA易损性的生物标志物。相反，PTA的发展和恢复似乎是由海马主要通路穹窿中的白质和灰质结构变化促进的。目前的研究结果揭示了PTA恢复的神经解剖学基础，并表征了创伤后功能障碍风险的白质生物标志物。
Anhedonic symptoms of posttraumatic stress disorder (PTSD) reflect deficits in reward processing that have significant functional consequences. Although recent evidence suggests that disrupted integrity of fronto-limbic circuitry is related to PTSD development, including anhedonic PTSD symptoms (post-trauma anhedonia; PTA), little is known about potential structural biomarkers of long-term PTA as well as structural changes in fronto-limbic pathways associated with recovery from PTA over time. We investigated associations between white matter microstructure, gray matter volume, and PTA in 75 recently traumatized individuals, with a subset of participants (n = 35) completing follow-up assessment 12 months after trauma exposure. Deterministic tractography and voxel-based morphometry were used to assess changes in white and gray matter structure associated with changes in PTA. Reduced fractional anisotropy (FA) of the uncinate fasciculus at around the time of trauma predicted greater PTA at 12 months post-trauma. Further, increased FA of the fornix over time was associated with lower PTA between 1- and 12-months post-trauma. Increased gray matter volume of the ventromedial PFC and precuneus over time was also associated with reduced PTA. Microstructure of the uncinate fasciculus, an amygdala-prefrontal white matter connection, may represent a biomarker of vulnerability for later PTA. Conversely, development and recovery from PTA appears to be facilitated by white and gray matter structural changes in a major hippocampal pathway, the fornix. The present findings shed new light on neuroanatomical substrates of recovery from PTA and characterize white matter biomarkers of risk for posttraumatic dysfunction.
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影响因子：
4.2
作者：
Coloigner, Julie;Batail, Jean-Marie;Drapier, Dominique
通讯作者：
Drapier, Dominique
DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
影响因子：
5
作者：
Armour C
通讯作者：
Armour C
影响因子：
4.8
作者：
Fani, Negar;Michopoulos, Vasiliki;Stevens, Jennifer S.
通讯作者：
Stevens, Jennifer S.
影响因子：
3.3
作者：
Feeny, NC;Zoellner, LA;Foa, EB
通讯作者：
Foa, EB