The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics.
The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics.
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DOI：
10.1016/j.semcdb.2010.08.007
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发表时间：
2010-12
影响因子：
7.3
通讯作者：
Moasser MM
中科院分区：
文献类型：
--
作者：
Amin DN;Campbell MR;Moasser MM
许多类型的人类癌症的特征在于酪氨酸激酶受体的人表皮生长因子受体（HER）家族的失调。在一些癌症中，导致个体HER家族成员过度活跃的基因组事件与这些癌症的发病机制在病因学上相关，并且构成了其致瘤行为的驱动信号功能。HER3在这个家族中脱颖而出，是唯一缺乏催化激酶功能的成员。尚未发现具有驱动HER3扩增或突变的癌症，并且其在肿瘤中表达的研究仅具有微弱的刺激性。然而，大量的证据，主要来自实验模型，现在表明，它的非催化功能是至关重要的，在许多癌症驱动的“她的家庭伙伴。此外，对HER家族激活机制的新见解提供了HER3激酶结构域功能的明确证据。强调HER3功能的结构、机制和实验证据的融合可能在肿瘤发生中至关重要，现在已经导致重新努力鉴定癌症或癌症亚型，其中HER3功能可能在肿瘤进展或耐药性中很重要。现在看来，它未能获得癌基因的传统定义，使得HER3的肿瘤促进功能逃避了癌症治疗的影响。但实验科学现在已经揭示了HER3在癌症生物学中的低调作用，下一代癌症疗法无疑会因此表现得更好。
Many types of human cancer are characterized by deregulation of the human epidermal growth factor receptor (HER) family of tyrosine kinase receptors. In some cancers, genomic events causing overactivity of individual HER family members are etiologically linked with the pathogenesis of these cancers, and constitute the driving signaling function underlying their tumorigenic behavior. HER3 stands out among this family as the only member lacking catalytic kinase function. Cancers with driving HER3 amplifications or mutations have not been found, and studies of its expression in tumors have been only weakly provocative. However, substantial evidence, predominantly from experimental models, now suggest that its non-catalytic functions are critically important in many cancers driven by its’ HER family partners. Furthermore, new insights into the mechanism of activation in the HER family has provided clear evidence of functionality in the HER3 kinase domain. The convergence of structural, mechanistic, and experimental evidence highlighting HER3 functions that may be critical in tumorigenesis have now led to renewed efforts towards identification of cancers or subtypes of cancers wherein HER3 function may be important in tumor progression or drug resistance. It appears now that its failure to earn the traditional definition of an oncogene has allowed the tumor promoting functions of HER3 to elude the effects of cancer therapeutics. But experimental science has now unmasked the unpretentious role of HER3 in cancer biology, and the next generation of cancer therapies will undoubtedly perform much better because of it.
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影响因子：
11.5
作者：
Cristofanilli, Massimo;Valero, Vicente;Magill, Patrick J.
通讯作者：
Magill, Patrick J.
影响因子：
3.3
作者：
Dong, JY;Opresko, LK;Wiley, HS
通讯作者：
Wiley, HS
影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
6.4
作者：
Desruisseau, S;Palmari, J;Berthois, Y
通讯作者：
Berthois, Y
DOI：
10.1186/bcr1664
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Carney WP;Leitzel K;Ali S;Neumann R;Lipton A
通讯作者：
Lipton A