Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits.

Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits.
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用于社交互动的神经电路:从微电路到输入输出电路

DOI:
10.3389/fncir.2021.768294
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发表时间:
2021
影响因子:
3.5
通讯作者:
Bai Z
Bai Z
中科院分区:
医学3区
文献类型:
--
作者:
Xu S;Jiang M;Liu X;Sun Y;Yang L;Yang Q;Bai Z

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社会行为需要对社会信息做出反应,需要通过一个涉及注意力、记忆、动机和情绪的复杂认知过程来感知和整合社会线索。社会行为背后的神经生物学和分子机制在物种之间是高度保守的,观察到的社会行为的种间和种内差异在很大程度上可以通过保守的神经网络的不同活动来解释。然而,涉及社会行为的神经微电路和精确网络仍然是个谜。在这篇综述中,我们总结了不同社会相互作用的分子、细胞和网络水平上的微电路和输入输出电路,如社会探索、社会等级、社会记忆和社会偏好。这篇综述提供了关于多个微电路和输入输出电路如何汇聚在内侧前额叶皮质、海马体和杏仁核以调节复杂的社会行为的广泛观点,以及更好地控制病理发展的潜在的新观点。
Social behaviors entail responses to social information and requires the perception and integration of social cues through a complex cognition process that involves attention, memory, motivation, and emotion. Neurobiological and molecular mechanisms underlying social behavior are highly conserved across species, and inter- and intra-specific variability observed in social behavior can be explained to large extent by differential activity of a conserved neural network. However, neural microcircuits and precise networks involved in social behavior remain mysterious. In this review, we summarize the microcircuits and input-output circuits on the molecular, cellular, and network levels of different social interactions, such as social exploration, social hierarchy, social memory, and social preference. This review provides a broad view of how multiple microcircuits and input-output circuits converge on the medial prefrontal cortex, hippocampus, and amygdala to regulate complex social behaviors, as well as a potential novel view for better control over pathological development.
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