Social Dominance Modulates Stress-induced Neural Activity in Medial Prefrontal Cortex Projections to the Basolateral Amygdala.
Social Dominance Modulates Stress-induced Neural Activity in Medial Prefrontal Cortex Projections to the Basolateral Amygdala.
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DOI：
10.1016/j.neuroscience.2018.07.042
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发表时间：
2018-09-15
期刊：
影响因子：
3.3
通讯作者：
Cooper MA
中科院分区：
文献类型：
--
作者：
Dulka BN;Bress KS;Grizzell JA;Cooper MA
压力是一个促成因素的病因学的几种情绪和焦虑症，社会失败模型被用来调查的生物学基础的压力相关的精神病理学。雄性叙利亚仓鼠具有高度的攻击性和领土性，但在社会失败后，它们表现出条件性失败（CD）反应，其特征是增加顺从行为，并未能保护其家园领土免受较小的非攻击性入侵者的攻击。社会地位占主导地位的仓鼠显示增加c-Fos表达的边缘下（IL）皮质后，社会失败，并显示减少CD响应测试相比，下属和控制。在这项研究中，我们测试的预测，占主导地位的将显示增加失败诱导的神经活动在IL，但不前边缘（PL）或腹侧海马（vHPC），神经元发送传出投射到基底外侧杏仁核（BLA）相比，下属。我们进行了c-Fos和霍乱毒素B（CT B）的双重免疫组织化学，发现优势细胞在IL和PL中显示出显著更大比例的双标记c-Fos + CT B细胞。此外，优势显示更多的c-Fos阳性细胞在IL和PL，但不是vHPC，相比，下属。这些研究结果表明，占主导地位的仓鼠选择性激活IL和PL，但不是vHPC，预测杏仁核在社会失败，这可能是负责减少CD反应。该项目扩展了我们对抵抗社会压力的神经回路的理解，这是朝着描绘预防和治疗压力相关精神病理学的基于回路的方法迈出的重要一步。
Stress is a contributing factor in the etiology of several mood and anxiety disorders, and social defeat models are used to investigate the biological basis of stress-related psychopathologies. Male Syrian hamsters are highly aggressive and territorial, but after social defeat they exhibit a conditioned defeat (CD) response which is characterized by increased submissive behavior and a failure to defend their home territory against a smaller, non-aggressive intruder. Hamsters with dominant social status show increased c-Fos expression in the infralimbic (IL) cortex following social defeat and display a reduced CD response at testing compared to subordinates and controls. In this study, we tested the prediction that dominants would show increased defeat-induced neural activity in IL, but not prelimbic (PL) or ventral hippocampus (vHPC), neurons that send efferent projections to the basolateral amygdala (BLA) compared to subordinates. We performed dual immunohistochemistry for c-Fos and cholera toxin B (CTB) and found that dominants display a significantly greater proportion of double-labeled c-Fos + CTB cells in both the IL and PL. Furthermore, dominants display more c-Fos-positive cells in both the IL and PL, but not vHPC, compared to subordinates. These findings suggest that dominant hamsters selectively activate IL and PL, but not vHPC, projections to the amygdala during social defeat, which may be responsible for their reduced CD response. This project extends our understanding of the neural circuits underlying resistance to social stress, which is an important step towards delineating a circuit-based approach for the prevention and treatment of stress-related psychopathologies.
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DOI：
10.1523/jneurosci.4904-07.2008
发表时间：
2008-08-06
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hefner K;Whittle N;Juhasz J;Norcross M;Karlsson RM;Saksida LM;Bussey TJ;Singewald N;Holmes A
通讯作者：
Holmes A
影响因子：
3.5
作者：
Been, Laura E.;Petrulis, Aras
通讯作者：
Petrulis, Aras
影响因子：
10.6
作者：
Davidson, RJ
通讯作者：
Davidson, RJ
影响因子：
3.5
作者：
Huhman, Kim L.
通讯作者：
Huhman, Kim L.
影响因子：
3.5
作者：
Huhman, KL;Solomon, MB;Jasnow, AM
通讯作者：
Jasnow, AM