What causes alopecia areata?
What causes alopecia areata?
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DOI：
10.1111/exd.12209
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发表时间：
2013-09
影响因子：
3.6
通讯作者：
Paus R
中科院分区：
文献类型：
--
作者：
McElwee KJ;Gilhar A;Tobin DJ;Ramot Y;Sundberg JP;Nakamura M;Bertolini M;Inui S;Tokura Y;King LE Jr;Duque-Estrada B;Tosti A;Keren A;Itami S;Shoenfeld Y;Zlotogorski A;Paus R
斑秃（alopecia areata，AA）是一种常见的自身免疫性疾病，其发病机制一直是皮肤科、毛发生物学和免疫学研究的热点。同时，受影响的病人和照顾他们的医生都越来越沮丧，因为仍然没有完全令人满意的治疗方法。这种挫败感的大部分原因是AA的病理生物学仍然不清楚，没有一个单一的AA发病机制概念可以声称是普遍接受的。事实上，一些研究人员仍然怀疑这是否是一种自身免疫性疾病，CD8+ T细胞，CD4+ T细胞和NKGD2+ NK或NKT细胞的相对重要性以及遗传因素在AA发病机制中的确切作用仍然是争论的焦点。此外，AA是一种疾病，一系列不同的疾病实体或只是正常毛囊对免疫介导的损伤的反应模式？在过去的十年中，在基础AA相关的研究，在开发新的模型的预防相关的AA研究和在确定新的治疗药物和未来的AA管理的目标，取得了实质性的进展。这就要求对目前流行的AA病理生物学概念进行重新评估和公开辩论。目前的争议功能承担了这一挑战，希望吸引更多的皮肤生物学家，免疫学家和专业的自身免疫专家对这种生物学上迷人的和临床上重要的模型疾病。
The pathobiology of alopecia areata (AA), one of the most frequent autoimmune diseases and a major unsolved clinical problem, has intrigued dermatologists, hair biologists and immunologists for decades. Simultaneously, both affected patients and the physicians who take care of them are increasingly frustrated that there is still no fully satisfactory treatment. Much of this frustration results from the fact that the pathobiology of AA remains unclear, and no single AA pathogenesis concept can claim to be universally accepted. In fact, some investigators still harbour doubts whether this even is an autoimmune disease, and the relative importance of CD8+ T cells, CD4+ T cells and NKGD2+ NK or NKT cells and the exact role of genetic factors in AA pathogenesis remain bones of contention. Also, is AA one disease, a spectrum of distinct disease entities or only a response pattern of normal hair follicles to immunologically mediated damage? During the past decade, substantial progress has been made in basic AA-related research, in the development of new models for translationally relevant AA research and in the identification of new therapeutic agents and targets for future AA management. This calls for a re-evaluation and public debate of currently prevalent AA pathobiology concepts. The present Controversies feature takes on this challenge, hoping to attract more skin biologists, immunologists and professional autoimmunity experts to this biologically fascinating and clinically important model disease.
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DOI：
10.4049/jimmunol.1100657
发表时间：
2012-01-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Alli R;Nguyen P;Boyd K;Sundberg JP;Geiger TL
通讯作者：
Geiger TL
影响因子：
7.3
作者：
Harries, Matthew J.;Meyer, Katja;Paus, Ralf
通讯作者：
Paus, Ralf
影响因子：
3.6
作者：
Bertolini, Marta;Gilhar, Amos;Paus, Ralf
通讯作者：
Paus, Ralf
影响因子：
10.3
作者：
Ghoreishi, M.;Martinka, M.;Dutz, J. P.
通讯作者：
Dutz, J. P.
影响因子：
6.5
作者：
Betz, Regina C.;Pforr, Jana;Noethen, Markus M.
通讯作者：
Noethen, Markus M.